NCT07713706Enrolling by invitation
Neural Mechanisms for Stopping Ongoing Speech Production (Study 2)
Source: ClinicalTrials.gov · Last updated 5 Nov 2026
Brief summary (registry, in English)
Speech and communication disorders often result in aberrant control of the timing of speech production, such as making improper stops at places where they should not be. During normal speech, the ability to stop when necessary is important for maintaining turn-taking in a smooth conversation. Existing studies have largely investigated neural circuits that support the preparation and generation of speech sounds. It is believed that activity in the prefrontal and premotor cortical areas facilitates high-level speech control and activity in the ventral part of the sensorimotor cortex controls the articulator (e.g. lip, jaw, tongue) movements. However, little is known about the neural mechanism controlling a sudden and voluntary stop of speech. Traditional view attributes this to a disengagement of motor signals while recent evidence suggested there may be an inhibitory control mechanism. This gap in knowledge limits our understanding of disorders like stuttering and aphasia, where deficits in speech timing control are among the common symptoms. The overall goal of this study is to determine how the brain controls the stopping of ongoing speech production to deepen our understanding of speech and communication in normal and impaired conditions.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 12 (estimated)
- First submitted
- 14 Jul 2026
- Start date
- Jan 2027
- Primary completion date
- 31 Jul 2028
- Lead sponsor
- University of Pittsburgh
- Diseases
- Epilepsy
- NCT number
- NCT07713706
What you commit to
- Study type: Interventional
- Planned participants: 12
- From Jan 2027 to the primary completion date, 31 Jul 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of autism or ADHD
Other
- Individuals with intellectual disability
- Lack of fluent English comprehension/production
- Inadequate speech ability for the research tasks.
Who the study is looking for
- Undergoing iEEG placement in regions of interest (e.g., in the frontal or temporal cortex) for clinically necessary localization of epileptic foci or language mapping
- Fluent English speakers
- Within the normal range for cognitive, speech-language, and hearing capacity
- Normal or corrected-to-normal visual acuity
Age in the registry: 8 years to 26 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UPMC Children's Hospital of Pittsburgh Coordinator of this site? Confirm its status | Pittsburgh | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.