NCT07713719Recruiting
Arterial Stiffness and Endothelial Function in Heart Failure
Pathophysiology of Heart Failure: the Role of Arterial Stiffness and Endothelial Function
Source: ClinicalTrials.gov · Last updated 21 Oct 2026
Brief summary (registry, in English)
Heart Failure (HF) is a global condition affecting at least 26 million people worldwide. Despite advances in treatment, HF patients continue to experience poor health outcomes. This study aims to improve understanding of the role of blood vessels in people with heart failure. The study will assess how arterial stiffness (how stiff blood vessels are) and endothelial function (how well the lining of blood vessels functions) change over time and respond to treatments received as part of routine clinical care. Blood vessel function and heart performance will be assessed at three time points: * At baseline (when Patients are first diagnosed with heart failure). * After completing 4 ± 2 weeks of heart-failure medicines prescribed to patients as part of their routine clinical care. * After completion of cardiac rehabilitation program as a part of their routine clinical care. All assessments are non-invasive.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 3 Jul 2026
- Start date
- 18 Sept 2026
- Primary completion date
- Jun 2028
- Lead sponsor
- Coventry University
- Diseases
- Heart failure
- NCT number
- NCT07713719
What you commit to
- Study type: Observational
- Planned participants: 50
- From 18 Sept 2026 to the primary completion date, Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- • Inability to provide verbal informed consent.
- Presenting with severe symptoms; major co-morbidity or other alternative diagnoses (e.g., malignancy, severe respiratory disease, severe mental health problem/s).
- Recent acute coronary syndrome (within 60 days).
- Severe physical disability preventing independence.
- Severe renal insufficiency.
- Pregnancy (Present or planned).
- Life expectancy less than 12 months
Who the study is looking for
- Male and female ≥ 18 years old.
- Have a confirmed de-novo diagnosis of Heart failure with preserved ejection fraction or Heart failure with reserved ejection fraction. Common HF phenotypes (e.g., hypertension, diabetes, obesity) will be recorded as part of routine baseline data but will not influence recruitment or sampling. .
- Have stable Heart failure in the opinion of the investigator.
- Have ability, in the opinion of the investigator, to participate in study activities.
- Able to provide written informed consent.
Age in the registry: 18 years to 90 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University Hospitals Coventry and Warwickshire Coordinator of this site? Confirm its status | Coventry | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.