NCT07718815Recruiting
HLA B Leader in Patients With Psoriatic Arthritis
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
Psoriatic arthritis (PsA), a chronic immune-mediated heterogeneous inflammatory disease characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis and dactylitis), usually occurs in patients with psoriasis. The spondyloarthritides (SPs) (of which psoriasis is one) are a group of inflammatory diseases that share an association with the HLA-B27 MHC class I molecule. Given this association, these diseases are classically regarded as disorders of adaptive immunity. In bone marrow donation, HLA-B exon 1 dimorphism (HLAB leader) is associated with risk of graft- versus-host disease, relapse and overall survival after unrelated hematopoietic cell transplantation (UHCT), haploidentical UHCT and cord transplantation. In the literature, there are no studies suggesting the involvement of the HLA B leader gene in MS and RPs. The main aim of this study is to compare the presence of the HLA B leader gene between a group of patients with psoriatic arthritis and a healthy group without inflammatory disease.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 658 (estimated)
- First submitted
- 16 Jul 2026
- Start date
- 6 May 2025
- Primary completion date
- Sept 2026
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Diseases
- Psoriasis, Psoriatic arthritis
- NCT number
- NCT07718815
What you commit to
- Study type: Interventional
- Planned participants: 658
- From 6 May 2025 to the primary completion date, Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Patient or control not understanding French
- Patient not included in the Amiens Picardie University Hospital's "Psoriatic Rheumatism" cohort, or control not included in the Amiens Picardie University Hospital's bone marrow donor cohort.
- Patient or control objecting to participation in the study
Who the study is looking for
- For the "Patient" group:
- Patient over 18 years of age
- Patient affiliated to a social security scheme
- Patient with psoriatic arthritis according to the CASPAR 2006 classification, followed at the CHU Amiens-Picardie.
- For the "control" group:
- Individuals over 18 years of age
- Individual affiliated to a social security scheme
- Individual having agreed to participate in the study
- Individuals with no inflammatory or autoimmune diseases
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chu Amiens Picardie Coordinator of this site? Confirm its status | Amiens | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.