NCT07719387Enrolling by invitation
Vagal Nerve Stimulation To Enhance Cognition and Learning
Evaluation of Vagus Nerve Stimulation Paired With Cognitive Training to Enhance Learning and Memory and Neural Plasticity in Post-Stroke Patients
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
The purpose of this study is to find out whether pairing vagus nerve stimulation (VNS) with cognitive training can improve memory and language learning in people who have previously used VNS therapy for movement rehabilitation after a stroke. VNS has been previously used to support motor recovery after stroke, but its effect on cognitive learning is not yet fully understood. This study is enrolling individuals who already have a VNS device implanted and have successfully completed VNS-assisted movement therapy. The investigators aim to explore whether continuing to use the device during a language learning program may also support memory and cognitive improvement. This is a research study, which means the use of VNS for cognitive enhancement is experimental and not currently part of standard treatment. An exploratory MRI/fMRI component also will assess whether VNS-paired language learning is associated with changes in task-based activation and resting-state functional connectivity in language, memory, salience/arousal, and frontoparietal cognitive-control networks. The information learned may help guide future approaches to stroke rehabilitation and cognitive recovery.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 26 Jun 2026
- Start date
- 17 Nov 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- Stony Brook University
- Diseases
- Stroke
- NCT number
- NCT07719387
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 17 Nov 2025 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unable to commit to 6 weeks of therapy
Other illness
- Significant uncorrected hearing or visual impairment
- Any medical condition that, in the investigator's judgment, would make participation unsafe
Age
- Younger than 22 years of age
Other
- Severe aphasia
- Unable to read and/or write in English
- Pregnancy
- Prisoner or ward of the state
Who the study is looking for
- Adults aged 22 years or older
- History of stroke
- Implanted with a Vivistim™ VNS device
- Monolingual in English
- Home-dwelling and independent in activities of daily living
- No prior language training in the selected language of learning
- Tolerated 6 weeks of movement therapy at 0.8 mA without incident and has used the device for at-home stimulation without incident
- Willing and able to participate in a six-week at-home intervention
- Clinically stable, without major concurrent medical conditions that would interfere with study participation
Age in the registry: 22 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stony Brook University Hospital Coordinator of this site? Confirm its status | Stony Brook | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.