A Multicenter, Prospective, Open-Label, Randomized Controlled Clinical Study of Orelabrutinib Combined With Obinutuzumab and Lenalidomide Versus Obinutuzumab Plus Chemotherapy for Treatment-Naive Follicular Lymphoma

Prior treatment

• Receiving concurrent anti-tumor therapy (for lymphoma or other malignancies).
• Requiring continuous treatment with strong or moderate CYP3A inhibitors or CYP3A inducers (see Appendix 3). Subjects who have taken strong/moderate CYP3A inhibitors or inducers within 7 days prior to the first dose of study drug (or within less than 5 half-lives of such medications) are excluded.
• History of stroke or intracranial hemorrhage within 6 months before the first dose of study drug.
• Inability to swallow capsules, or presence of diseases that significantly impair gastrointestinal function, such as malabsorption syndrome, bariatric surgery, inflammatory bowel disease, partial or complete intestinal obstruction.
  • Other uncontrolled concomitant medical conditions deemed by the investigator to interfere with study participation. Any life-threatening disease, medical condition or organ dysfunction that may compromise subject safety, interfere with the absorption or metabolism of oral targeted agents, or expose study outcomes to excessive risk, as judged by the investigator.

Other illness

• Uncontrolled cardiovascular and cerebrovascular diseases, coagulation disorders, connective tissue diseases, severe infectious diseases, etc.
• Human immunodeficiency virus (HIV)-positive subjects.
• HBV screening requirements: Subjects with positive hepatitis B surface antigen (HBsAg) must undergo HBV DNA testing; those with HBV DNA \< 10³ IU/mL are eligible for enrollment. Subjects with negative HBsAg but positive hepatitis B core antibody (HBcAb) (regardless of hepatitis B surface antibody \[HBsAb\] status) must also undergo HBV DNA testing; those with HBV DNA \< 10³ IU/mL are eligible for enrollment.
• Subjects with psychiatric disorders, or those with known/suspected poor compliance to the study protocol.

Lab values

• Abnormal laboratory parameters at screening (unless attributed to follicular lymphoma):
  • Absolute neutrophil count \< 1.5 × 10⁹/L
  • Platelet count \< 80 × 10⁹/L; if bone marrow involvement is present, platelet count \< 50 × 10⁹/L
  • Alanine transaminase (ALT) or aspartate transaminase (AST) \> 2 × upper limit of normal (ULN); alkaline phosphatase (AKP) or bilirubin \> 1.5 × ULN
  • Serum creatinine \> 1.5 × ULN OR estimated glomerular filtration rate (eGFR) \< 40 mL/min/1.73 m² (calculated via the Cockcroft-Gault equation or Modification of Diet in Renal Disease \[MDRD\] equation)
• Left ventricular ejection fraction (LVEF) \< 50%.

• Subjects with histopathologically confirmed follicular lymphoma (FL) Grade 1-3A;
• Subjects who have never received prior anti-lymphoma therapy;
• Age ≥ 18 years old;
• Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2;
• Adequate bone marrow, hepatic and renal function, defined as:
  • 1）Absolute neutrophil count (ANC) \> 1,000/μL; platelet count \> 50,000/mm³; hemoglobin \> 80 g/dL; 2）Alanine transaminase (ALT) and aspartate transaminase (AST) \< 3 × upper limit of normal (ULN); 3）Total serum bilirubin \< 1.5 × ULN (patients with Gilbert syndrome are eligible); serum creatinine \< 2 × ULN OR creatinine clearance \> 50 mL/min; 6、Tumor tissue available for testing (fresh tissue preferred; archived paraffin-embedded tissue is acceptable); 7、Women of childbearing potential with a negative pregnancy test prior to Day 1 of treatment, who agree to use effective contraception throughout the study period and for at least 1 year after completion of study treatment; 8、Written informed consent obtained from the subject or their legal authorized representative prior to any study-specific examinations or procedures.