NCT07720271RecruitingPhase 3
AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight
Efficacy and Safety of Once-daily Oral Zenagamtide in Participants With Obesity (AMAZE 9)
Source: ClinicalTrials.gov · Last updated 28 Sept 2026
Brief summary (registry, in English)
The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 950 (estimated)
- First submitted
- 17 Jul 2026
- Start date
- 31 Aug 2026
- Primary completion date
- 27 Jun 2028
- Lead sponsor
- Novo Nordisk A/S
- Diseases
- Obesity
- NCT number
- NCT07720271
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 950
- From 31 Aug 2026 to the primary completion date, 27 Jun 2028
- 41 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.
Other illness
- History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
Lab values
- Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening.
Who the study is looking for
- Male or female (sex at birth).
- Age 18 and older (both inclusive) at time of signing the informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (41)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Amarillo Medical Specialists Coordinator of this site? Confirm its status | Amarillo | United States | Recruiting |
| Pinnacle Research Group, LLC Coordinator of this site? Confirm its status | Anniston | United States | Recruiting |
| Washington Cntr Weight Mgmt Coordinator of this site? Confirm its status | Arlington | United States | Not yet recruiting |
| Univ of Colorado at Denver Coordinator of this site? Confirm its status | Aurora | United States | Recruiting |
| Univ of Alabama Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
| Northern Pines Hlth Ctr, PC Coordinator of this site? Confirm its status | Buckley | United States | Recruiting |
| Medical Uni of SC Charleston Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
| Great Lakes Clinical Trials Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| StudyMetrix Research, LLC Coordinator of this site? Confirm its status | City of Saint Peters | United States | Recruiting |
| Hope Clin Res & Wellness Coordinator of this site? Confirm its status | Conyers | United States | Recruiting |
| Clinical Res Collaborative Coordinator of this site? Confirm its status | Cumberland | United States | Recruiting |
| North Texas Endocrine Center Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Brain Matters Research Coordinator of this site? Confirm its status | Delray Beach | United States | Recruiting |
| Northeast Research Institute Coordinator of this site? Confirm its status | Fleming Island | United States | Recruiting |
| Providence Medical Foundation Coordinator of this site? Confirm its status | Fullerton | United States | Recruiting |
| Medication Mgmnt, LLC_Grnsboro Coordinator of this site? Confirm its status | Greensboro | United States | Recruiting |
| Clinical Investigation Spec Gurnee Coordinator of this site? Confirm its status | Gurnee | United States | Recruiting |
| Miguel Rebollar PA Coordinator of this site? Confirm its status | Hialeah | United States | Recruiting |
| East West Medical Research Institute_Honolulu Coordinator of this site? Confirm its status | Honolulu | United States | Recruiting |
| Midwest Inst For Clin Res Coordinator of this site? Confirm its status | Indianapolis | United States | Not yet recruiting |
| Jacksonville Ctr Clin Res Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Palm Research Center Inc Coordinator of this site? Confirm its status | Las Vegas | United States | Recruiting |
| Torrance Clinical Research Institute, Inc. Coordinator of this site? Confirm its status | Lomita | United States | Recruiting |
| South Broward Research LLC Coordinator of this site? Confirm its status | Miramar | United States | Recruiting |
| Chambliss Clinical Trials, LLC Coordinator of this site? Confirm its status | Montgomery | United States | Recruiting |
| Health Res of Hampton Roads Coordinator of this site? Confirm its status | Newport News | United States | Recruiting |
| Comprehensive Weight Ctrl Prog Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Lynn Institute of Norman Coordinator of this site? Confirm its status | Norman | United States | Recruiting |
| Coastal Carolina Research Ctr Coordinator of this site? Confirm its status | North Charleston | United States | Recruiting |
| Florida Institute For Clinical Research, LLC Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| Clinical Neuroscience Solution Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| Oviedo Medical Research, LLC Coordinator of this site? Confirm its status | Oviedo | United States | Recruiting |
| Accellacare of Raleigh Coordinator of this site? Confirm its status | Raleigh | United States | Recruiting |
| National Clin Res Inc. Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
| Accellacare-Salisbury PMG Res Coordinator of this site? Confirm its status | Salisbury | United States | Recruiting |
| Hillcrest Clinical Research Coordinator of this site? Confirm its status | Simpsonville | United States | Recruiting |
| Evanston Premier Hlthcr Res Coordinator of this site? Confirm its status | Skokie | United States | Recruiting |
| Endeavor Health Coordinator of this site? Confirm its status | Skokie | United States | Recruiting |
| Spartanburg Medical Research Coordinator of this site? Confirm its status | Spartanburg | United States | Recruiting |
| Diablo Clinical Research, Inc. Coordinator of this site? Confirm its status | Walnut Creek | United States | Recruiting |
| Accellacare and KDCILM, LLC Coordinator of this site? Confirm its status | Wilmington | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.