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NCT07720271RecruitingPhase 3

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

Efficacy and Safety of Once-daily Oral Zenagamtide in Participants With Obesity (AMAZE 9)

Source: ClinicalTrials.gov · Last updated 28 Sept 2026

Brief summary (registry, in English)

The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Status (registry)
Recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
950 (estimated)
First submitted
17 Jul 2026
Start date
31 Aug 2026
Primary completion date
27 Jun 2028
Lead sponsor
Novo Nordisk A/S
Diseases
Obesity
NCT number
NCT07720271

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 950
  • From 31 Aug 2026 to the primary completion date, 27 Jun 2028
  • 41 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.

Other illness

  • History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.

Lab values

  • Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening.

Who the study is looking for

  • Male or female (sex at birth).
  • Age 18 and older (both inclusive) at time of signing the informed consent.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (41)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Amarillo Medical Specialists
Coordinator of this site? Confirm its status
AmarilloUnited StatesRecruiting
Pinnacle Research Group, LLC
Coordinator of this site? Confirm its status
AnnistonUnited StatesRecruiting
Washington Cntr Weight Mgmt
Coordinator of this site? Confirm its status
ArlingtonUnited StatesNot yet recruiting
Univ of Colorado at Denver
Coordinator of this site? Confirm its status
AuroraUnited StatesRecruiting
Univ of Alabama Birmingham
Coordinator of this site? Confirm its status
BirminghamUnited StatesRecruiting
Northern Pines Hlth Ctr, PC
Coordinator of this site? Confirm its status
BuckleyUnited StatesRecruiting
Medical Uni of SC Charleston
Coordinator of this site? Confirm its status
CharlestonUnited StatesRecruiting
Great Lakes Clinical Trials
Coordinator of this site? Confirm its status
ChicagoUnited StatesRecruiting
StudyMetrix Research, LLC
Coordinator of this site? Confirm its status
City of Saint PetersUnited StatesRecruiting
Hope Clin Res & Wellness
Coordinator of this site? Confirm its status
ConyersUnited StatesRecruiting
Clinical Res Collaborative
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CumberlandUnited StatesRecruiting
North Texas Endocrine Center
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DallasUnited StatesRecruiting
Brain Matters Research
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Delray BeachUnited StatesRecruiting
Northeast Research Institute
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Fleming IslandUnited StatesRecruiting
Providence Medical Foundation
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FullertonUnited StatesRecruiting
Medication Mgmnt, LLC_Grnsboro
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GreensboroUnited StatesRecruiting
Clinical Investigation Spec Gurnee
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GurneeUnited StatesRecruiting
Miguel Rebollar PA
Coordinator of this site? Confirm its status
HialeahUnited StatesRecruiting
East West Medical Research Institute_Honolulu
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HonoluluUnited StatesRecruiting
Midwest Inst For Clin Res
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IndianapolisUnited StatesNot yet recruiting
Jacksonville Ctr Clin Res
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JacksonvilleUnited StatesRecruiting
Palm Research Center Inc
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Las VegasUnited StatesRecruiting
Torrance Clinical Research Institute, Inc.
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LomitaUnited StatesRecruiting
South Broward Research LLC
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MiramarUnited StatesRecruiting
Chambliss Clinical Trials, LLC
Coordinator of this site? Confirm its status
MontgomeryUnited StatesRecruiting
Health Res of Hampton Roads
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Newport NewsUnited StatesRecruiting
Comprehensive Weight Ctrl Prog
Coordinator of this site? Confirm its status
New YorkUnited StatesRecruiting
Lynn Institute of Norman
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NormanUnited StatesRecruiting
Coastal Carolina Research Ctr
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North CharlestonUnited StatesRecruiting
Florida Institute For Clinical Research, LLC
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OrlandoUnited StatesRecruiting
Clinical Neuroscience Solution
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OrlandoUnited StatesRecruiting
Oviedo Medical Research, LLC
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OviedoUnited StatesRecruiting
Accellacare of Raleigh
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RaleighUnited StatesRecruiting
National Clin Res Inc.
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RichmondUnited StatesRecruiting
Accellacare-Salisbury PMG Res
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SalisburyUnited StatesRecruiting
Hillcrest Clinical Research
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SimpsonvilleUnited StatesRecruiting
Evanston Premier Hlthcr Res
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SkokieUnited StatesRecruiting
Endeavor Health
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SkokieUnited StatesRecruiting
Spartanburg Medical Research
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SpartanburgUnited StatesRecruiting
Diablo Clinical Research, Inc.
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Walnut CreekUnited StatesRecruiting
Accellacare and KDCILM, LLC
Coordinator of this site? Confirm its status
WilmingtonUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.