NCT07720661Withdrawn
Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment
COMFORT: Comparative Outcomes of Mammary Artery Harvesting: Infection, Occlusion Rates and Thoracic Pain Assessment
Source: ClinicalTrials.gov · Last updated 28 Jul 2026
Reason given: Registered too early. Completing the vanguard first which is registered separately.
Brief summary (registry, in English)
The COMFORT Trial is a randomized controlled superiority trial comparing skeletonized (SK) versus non-skeletonized (non-SK) harvesting of the left internal mammary artery (LIMA) to left anterior descending artery (LAD) graft in patients undergoing isolated coronary artery bypass grafting (CABG).
- Status (registry)
- Withdrawn
- Study type
- Interventional
- Enrollment
- 0 (actual)
- First submitted
- 17 Jul 2026
- Start date
- 1 Sept 2026
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- Hamilton Health Sciences Corporation
- Diseases
- Coronary artery disease
- NCT number
- NCT07720661
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Non-sternotomy surgical approach (e.g., minimally invasive, thoracotomy)
- Emergency surgery (defined as surgery required within 24 hours of presentation)
- History of prior sternotomy
- Currently receiving systemic antibiotics or with an active bacterial infection at the time of surgery
- History of chronic sternal pain prior to the index surgery
- Previous radiation therapy to the chest
Other illness
- Known allergy or contraindication to iodinated contrast media that cannot be managed with premedication
- Life expectancy less than 1.5 years due to non-cardiac conditions
Lab values
- Estimated glomerular filtration rate (eGFR) <30 mL/min/1.73m² at baseline (relative contraindication to CTA contrast) as determined based on each centre's laboratory standard.
Other
- Known left subclavian artery stenosis (>50%)
- Known pregnancy or plans for pregnancy during the study period
- Inability or unwillingness to comply with follow-up procedures including CTA at 1.5 years
Who the study is looking for
- Age 18 years or older
- Undergoing isolated CABG surgery with median sternotomy and a planned LIMA-LAD graft
- Provision of written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.