NCT07720765Recruiting
Optical Coherence Tomography in Neurological Practice: Utility and Applicability Across Neurological Diseases (OCt.IN.N)
A National, Monocentric, Prospective Cohort Study to Evaluate the Utility and Applicability of Optical Coherence Tomography in Neurological Clinical Practice
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
OCt.IN.N is a national, monocentric, prospective, observational cohort study evaluating the utility and applicability of Optical Coherence Tomography (OCT) in the diagnostic workup and longitudinal monitoring of neurological diseases. 840 patients with Central Nervous System neurological diseases (Multiple Sclerosis, Alzheimer's disease, Parkinson's disease, migraine/headache) and 210 age-matched healthy controls will undergo OCT examination at baseline and at 6, 12, 18, and 24 months of follow-up at IRCCS San Raffaele Hospital, Milan, Italy. OCT is a non-invasive, rapid, and reproducible technique that automatically measures the thickness of individual retinal layers. Retinal layer thicknesses and their longitudinal changes will be correlated with established clinical scales, neuroimaging, and biological markers used in routine neurological practice.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 1050 (estimated)
- First submitted
- 17 Jul 2026
- Start date
- Oct 2023
- Primary completion date
- Apr 2030
- Lead sponsor
- IRCCS San Raffaele
- NCT number
- NCT07720765
What you commit to
- Study type: Observational
- Planned participants: 1050
- From Oct 2023 to the primary completion date, Apr 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- For specific imaging modes using clearly visible light sources (MultiColor, FA, BAF): diagnosis of epilepsy or history of previous epileptic seizures.
Other illness
- Presence of any condition that, in the investigators' opinion, renders the subject unsuitable for the study.
- Presence of any condition that, in the investigators' opinion, renders the subject unsuitable for the study.
Other
- Refusal to participate or withdrawal of informed consent.
- Known or confirmed ocular pathology identified during examination (ophthalmological evaluation may be requested at the investigators' discretion).
- Inability to understand instructions given by investigators.
- Refusal to participate or withdrawal of informed consent.
- Known or confirmed ocular pathology identified during examination.
- Inability to understand instructions given by investigators.
Who the study is looking for
- Diagnosis of a Central Nervous System neurological disease (inflammatory diseases such as Multiple Sclerosis; neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease; migraine/headache) according to currently accepted diagnostic criteria for each condition.
- Age greater than 18 years.
- Signed informed consent to study participation.
- Willingness and ability to undergo all study visits and procedures.
- Absence of neurological disease.
- Age greater than 18 years.
- Signed informed consent to study participation.
- Willingness and ability to undergo all study visits and procedures.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| IRCCS Ospedale San Raffaele - Neurology and Neurophysiology Unit Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.