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NCT07721155Completed

Objective Neurocognitive Assessment of Young Children With Sickle Cell Disease by Eye-Tracking

Source: ClinicalTrials.gov · Last updated 22 Jul 2026

Brief summary (registry, in English)

Evidence indicates that Sickle Cell Disease (SCD) threatens neurodevelopmental outcome. Although children with SCD may be heterogeneously affected, neurocognitive impairment may already be present in toddlers. Neurocognitive functioning is an important determinant of adaptive daily life functioning later in life and is influenced by both the course of the disease and the often suboptimal environment in which afflicted children grow up. Early identification of children at the highest risk of neurocognitive impairment would enable the deployment of early interventions to mitigate the detrimental effects of SCD on the developing brain. In order to develop such interventions, a deeper understanding of the underlying pathophysiological mechanisms is required. Therefore the main aim is to study early neurocognitive functioning and development in children with SCD between the ages of 6 and 24 months old.

Status (registry)
Completed
Study type
Observational
Enrollment
93 (actual)
First submitted
22 Jun 2026
Start date
16 Mar 2023
Primary completion date
27 Nov 2025
Lead sponsor
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
NCT number
NCT07721155

What you commit to

  • Study type: Observational
  • Participants enrolled: 93
  • From 16 Mar 2023 to the primary completion date, 27 Nov 2025
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Diagnosis of visual impairment (which cannot be corrected by glasses)
  • Diagnosis of a (co-morbid) congenital developmental condition
  • Any neurological condition, unrelated to SCD, that could affect the central nervous system, such as brain trauma, epilepsy and meningitis/encephalitis.

Other

  • Refused informed consent from parents/care-taker

Who the study is looking for

  • Age 6 - 24 months old
  • Inhabitant of the Netherlands
  • Written informed consent from parent/caretaker.

Age in the registry: 6 months to 24 months · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Amsterdam UMC
Coordinator of this site? Confirm its status
AmsterdamNetherlandsUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.