NCT07721649Recruiting
Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)
Intrahospital Vaccination and Active Counseling Versus Active Counseling Alone to Increase Seasonal Influenza immUnization in Patients at High Cardiovascular Risk in Germany: The Randomized Controlled VACC-UP Study
Source: ClinicalTrials.gov · Last updated 13 Oct 2026
Brief summary (registry, in English)
The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS) or congestive heart failure (CHF), compared with active counseling alone, on influenza vaccination rates in patients at high cardiovascular risk. Patients are randomized 1:1 to either an offer of bedside intrahospital influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO) in addition to standardized active counseling (intervention group), or standardized active counseling plus the standard-of-care recommendation for ambulatory vaccination in the discharge papers (control group). The primary endpoint is the influenza vaccination rate at the end of the index season (March 31).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 482 (estimated)
- First submitted
- 18 Jul 2026
- Start date
- 30 Sept 2026
- Primary completion date
- Mar 2028
- Lead sponsor
- Stephan Baldus
- Diseases
- Heart failure, Coronary artery disease
- NCT number
- NCT07721649
What you commit to
- Study type: Interventional
- Planned participants: 482
- From 30 Sept 2026 to the primary completion date, Mar 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Already received seasonal influenza vaccination in the current season, based on self-reported vaccination status and/or vaccination certificate
Other illness
- Contraindication for vaccination (e.g., known allergy)
Lab values
- Laboratory-confirmed active influenza infection during the index hospitalization
Other
- Inability to provide written informed consent
Who the study is looking for
- Age 18 years or older
- Hospitalized due to acute coronary syndrome (ACS) or congestive heart failure (CHF) and fulfilling the criteria for influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO)
- Written informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Clinic III for Internal Medicine, University Hospital of Cologne Coordinator of this site? Confirm its status | Cologne | Germany | Recruiting |
| Department of Cardiology, University Heart and Vascular Centre Hamburg Coordinator of this site? Confirm its status | Hamburg | Germany | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.