NCT07728630Recruiting
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Adults With Newly Diagnosed Untreated Hypertension
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and vascular injury; however, their relationship with blood pressure and microvascular endothelial function in untreated hypertension remains insufficiently understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive adults and adults with newly diagnosed, untreated primary hypertension. In addition, the study will investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and established circulating biomarkers of endothelial activation. The findings may improve understanding of the role of EEVs in early hypertension and support their potential use as non-invasive biomarkers of endothelial dysfunction and cardiovascular risk.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 22 Jul 2026
- Start date
- 1 May 2026
- Primary completion date
- 30 Apr 2029
- Lead sponsor
- Josip Juraj Strossmayer University of Osijek
- Diseases
- High blood pressure
- NCT number
- NCT07728630
What you commit to
- Study type: Observational
- Planned participants: 80
- From 1 May 2026 to the primary completion date, 30 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous treatment with antihypertensive medication.
- Current use of oral contraceptives, hormone replacement therapy, or medications known to affect endothelial function.
Other illness
- Secondary hypertension.
- History of cardiovascular disease (except newly diagnosed primary hypertension in the hypertensive group).
- Diabetes mellitus.
- Chronic kidney disease.
- Cerebrovascular disease.
- Peripheral arterial disease.
- Acute or chronic inflammatory or infectious disease.
- Active malignancy.
Other
- Pregnancy or breastfeeding.
- Inability or unwillingness to provide informed consent.
Who the study is looking for
- Adults aged 18 years or older.
- Ability and willingness to provide written informed consent.
- Normotensive individuals or individuals with newly diagnosed, previously untreated primary hypertension, classified according to the European Society of Hypertension (ESH) guidelines.
- Ability to comply with all study procedures.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine Osijek Coordinator of this site? Confirm its status | Osijek | Croatia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.