NCT07728643Recruiting
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Children With Newly Diagnosed Untreated Primary Hypertension
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their role in pediatric hypertension remains poorly understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive children and children with newly diagnosed, untreated primary hypertension. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury in pediatric hypertension and support the development of non-invasive biomarkers for early cardiovascular risk assessment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 22 Jul 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 30 Apr 2029
- Lead sponsor
- Josip Juraj Strossmayer University of Osijek
- Diseases
- High blood pressure
- NCT number
- NCT07728643
What you commit to
- Study type: Observational
- Planned participants: 80
- From 1 Apr 2026 to the primary completion date, 30 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous antihypertensive treatment.
- Use of medications known to affect endothelial function.
Other illness
- Secondary hypertension.
- Congenital heart disease or other significant cardiovascular disease.
- Diabetes mellitus.
- Chronic kidney disease.
- Autoimmune or chronic inflammatory disease.
- Acute infection at the time of enrollment.
- Malignancy.
Other
- Inability to comply with study procedures.
Who the study is looking for
- Children and adolescents aged 6-17 years.
- Written informed consent from a parent or legal guardian and assent from the participant when appropriate.
- Normotensive status or newly diagnosed, previously untreated primary hypertension according to current pediatric hypertension guidelines.
- Ability to comply with study procedures.
Age in the registry: 6 years to 17 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine Osijek Coordinator of this site? Confirm its status | Osijek | Croatia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.