NCT07728656Recruiting
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy
Endothelial Extracellular Vesicles as Biomarkers of Blood Pressure-Induced Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 22 Jul 2026
- Start date
- 1 Apr 2026
- Primary completion date
- 30 Apr 2029
- Lead sponsor
- Josip Juraj Strossmayer University of Osijek
- Diseases
- High blood pressure
- NCT number
- NCT07728656
What you commit to
- Study type: Observational
- Planned participants: 80
- From 1 Apr 2026 to the primary completion date, 30 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Chronic hypertension diagnosed before pregnancy.
- Pre-existing diabetes mellitus.
- Chronic kidney disease.
- Autoimmune disease.
- Known cardiovascular disease.
- Active infection or inflammatory disease.
- Malignancy.
Other
- Multiple pregnancy.
- Inability or unwillingness to provide informed consent.
Who the study is looking for
- Pregnant women aged ≥18 years.
- Singleton pregnancy.
- Ability to provide written informed consent.
- Normotensive pregnancy or diagnosis of gestational hypertension or preeclampsia according to current clinical guidelines.
- Ability to comply with study procedures.
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Medicine Osijek Coordinator of this site? Confirm its status | Osijek | Croatia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.