NCT07729111Not yet recruiting
ACCELERATE-CMR for Coronary Artery Disease Detection
ACCELERATE-CMR: Accelerated Cardiovascular Magnetic Resonance for the Detection of Coronary Artery Disease - a Randomised Controlled Trial
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
Coronary heart disease occurs when the blood vessels that supply the heart become narrowed or blocked. It is a leading cause of illness and death in the UK. Accurate diagnosis is important because effective treatments are available, but current tests are invasive, uncomfortable, and carry some risks. Cardiovascular magnetic resonance (CMR), also known as a heart MRI scan, is a safe and accurate test for diagnosing coronary heart disease. However, access to CMR is limited because standard scans take around 45 to 50 minutes, restricting the number of patients who can be scanned. Researchers have developed a faster CMR scan that takes only 15 to 20 minutes. Previous studies suggest that this shorter scan provides similar accuracy to the standard scan while improving patient comfort. This study will recruit 2022 adults with suspected coronary heart disease from hospitals in the UK. Participants will be randomly assigned to receive either the standard CMR scan or the faster CMR scan. The study will compare whether the accelerated scan provides similar clinical outcomes to the standard scan and whether patients prefer it. If successful, the accelerated scan could increase access to CMR by allowing more patients to be scanned each day, and enabling more efficient use of NHS resources.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 2022 (estimated)
- First submitted
- 8 Jul 2026
- Start date
- Sept 2026
- Primary completion date
- Sept 2029
- Lead sponsor
- University of Leicester
- Diseases
- Coronary artery disease
- NCT number
- NCT07729111
What you commit to
- Study type: Interventional
- Planned participants: 2022
- From Sept 2026 to the primary completion date, Sept 2029
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Lab values
- standard exclusion criteria for clinical stress CMR i.e.:
- absolute contraindications to CMR (non-conditional cardiac implantable electronic devices, metallic implants/foreign bodies),
- contraindications to adenosine (severe pulmonary disease, sinus-node/high-grade atrioventricular disease)
- severe kidney dysfunction (estimated glomerular filtration rate \[eGFR\] \<30ml/min/1.73m2)
- uncontrolled arrhythmia or unstable chest pain
- severe claustrophobia
Other
- previous invasive coronary angiography (within 12 months) with normal angiographic assessment and referred for CMR diagnosis of CMD
Who the study is looking for
- patients \>18 years of age referred for routine clinical stress CMR:
- A) with chest pain or angina equivalent OR
- o B) with heart failure/suspected heart failure and referred for diagnosis of suspected CAD or evaluation of heart failure aetiology
- Willing and able to consent to participate in the trial
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.