NCT07729410Not yet recruiting
Eccentric Exercise Rehabilitation After Myocardial Infarction
Effects of Two-Week Eccentric Exercise-Based Cardiac Rehabilitation on Myokines, Exerkines, and Physical Function in Patients After Myocardial Infarction
Source: ClinicalTrials.gov · Last updated 27 Jul 2026
Brief summary (registry, in English)
This clinical trial will evaluate a two-week eccentric exercise program conducted as part of comprehensive cardiac rehabilitation in patients after a heart attack (myocardial infarction). Eccentric exercise involves muscle contractions while the muscles are lengthening and may allow the muscles to work at a relatively high load with a lower cardiovascular and metabolic demand than traditional exercise. The main aim of the study is to determine whether eccentric exercise affects blood levels of proteins released or regulated in response to physical activity, including musclin, interleukin-6, and myostatin. The study will also evaluate whether the program improves physical performance and functional capacity. Participants will complete eccentric cycling exercise on a semi-recumbent cycle ergometer during a two-week cardiac rehabilitation program. Blood samples and physical-function measurements will be collected before and after the intervention.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 22 Jul 2026
- Start date
- 22 Jul 2026
- Primary completion date
- 21 Jul 2027
- Lead sponsor
- Medical University of Gdansk
- Diseases
- Coronary artery disease
- NCT number
- NCT07729410
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 22 Jul 2026 to the primary completion date, 21 Jul 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Acute myocardial infarction within the first 4 days before planned initiation of exercise rehabilitation.
Other illness
- Any contraindication to exercise-based cardiac rehabilitation or exercise testing.
- Unstable angina.
- Symptomatic cardiac arrhythmias.
- Decompensated heart failure.
- Deep vein thrombosis.
- Symptomatic acquired second- or third-degree atrioventricular block without appropriate cardiac pacing.
- Poorly controlled arterial hypertension.
- Recent stroke or transient cerebral ischemic event.
- Any acute or uncontrolled non-cardiovascular condition that may interfere with exercise testing or worsen during exercise, including febrile illness, clinically significant electrolyte abnormalities, uncontrolled hyperthyroidism, or clinically significant anemia.
- Physical or cognitive impairment preventing safe completion of the study procedures, exercise testing, or training intervention.
Other
- Significant left main coronary artery stenosis considered a contraindication to exercise by the treating cardiologist.
- Symptomatic severe aortic stenosis.
- Acute pulmonary embolism or pulmonary infarction.
- Recent or mobile intracardiac thrombus.
- Acute myocarditis, endocarditis, or pericarditis.
- Aortic dissection.
- Inability or unwillingness to provide written informed consent.
Who the study is looking for
- Documented history of myocardial infarction confirmed by medical records.
- Qualification for stage I comprehensive inpatient cardiac rehabilitation.
- Clinically stable condition allowing participation in exercise-based cardiac rehabilitation.
- New York Heart Association functional class I or II.
- Moderate or good exercise tolerance, defined as an exercise capacity of at least 5 metabolic equivalents, assessed during an exercise test.
- No cardiovascular contraindications to exercise testing or participation in exercise-based cardiac rehabilitation.
- Ability to understand the study procedures and follow the instructions provided by the study personnel.
- Provision of written informed consent to participate in the study.
Age in the registry: 50 years to 75 years · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Florian Ceynowa Specialist Hospital in Wejherowo Coordinator of this site? Confirm its status | Wejherowo | Poland | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.