Analysis of Clinical Characteristics of Chronic Hepatitis B Combined With MAFLD in Different TCM Syndrome Types

Other illness

• Patients with decompensated cirrhosis (Child-Pugh grade C) or liver failure.
• Complicated with end-stage renal disease, malignant tumors, severe cardiovascular diseases and other severe systemic diseases.
• Patients with mental disorders who cannot cooperate with data collection and clinical evaluation.
• Patients with other confounding liver diseases interfering with the judgment of MAFLD and CHB.

Other

• Pregnant or lactating women.
• Long-term users of immunosuppressants.
• Patients with incomplete medical records that cannot support complete index analysis.

• Aged between 18 and 70 years old, male and female patients are both eligible.
• Meet the diagnostic criteria of chronic hepatitis B (CHB): HBsAg positive for more than 6 months, detectable HBV DNA, accompanied by abnormal liver function, hepatic inflammation or liver fibrosis, and other liver diseases are excluded.
• Diagnosed with metabolic associated fatty liver disease (MAFLD) confirmed by imaging examination (ultrasound, CT or MRI) with hepatic steatosis ≥5%; patients meet at least one metabolic abnormality standard: BMI ≥25kg/m², fasting glucose ≥5.6mmol/L or type 2 diabetes, hypertension, dyslipidemia; patients without other etiologies of liver injury such as alcoholic liver disease and drug-induced liver injury.
• Classified into 5 TCM syndrome types by experienced physicians through four diagnostic methods: spleen damp-heat syndrome, liver depression and spleen deficiency syndrome, spleen deficiency and phlegm-damp syndrome, damp-heat accumulation syndrome, damp-heat blood stasis syndrome.
• Patients fully understand the study content and voluntarily sign the written informed consent form.
• Complete clinical laboratory, imaging and four-diagnosis record data available for retrospective analysis.