NCT07731217CompletedPhase 4
IV DEXAMETHASONE VS. METHYLPREDNISOLONE IN CHILDREN WITH SEVERE ASTHMA EXACERBATION
INTRAVENOUS DEXAMETHASONE VERSUS METHYLPREDNISOLONE IN WITH SEVERE ASTHMA EXACERBATION: A RANDOMISED, OPEN-LABEL, SINGLE-CENTRE STUDY
Source: ClinicalTrials.gov · Last updated 28 Jul 2026
Brief summary (registry, in English)
The study aims to determine whether a two-day intravenous course of dexamethasone is non-inferior to a conventional five-day intravenous course of methylprednisolone in children presenting with severe asthma exacerbations. To answer this question, researchers randomly assign eligible children to receive either IV dexamethasone or IV methylprednisolone. The clinical response to the treatments is objectively evaluated and compared using the Pediatric Respiratory Assessment Measure (PRAM) score at the 4th hour of treatment and on the 2nd day following hospital discharge.
- Status (registry)
- Completed
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 129 (actual)
- First submitted
- 23 Jul 2026
- Start date
- 1 Sept 2025
- Primary completion date
- 1 Jul 2026
- Lead sponsor
- Istanbul Medeniyet University
- Diseases
- Asthma
- NCT number
- NCT07731217
What you commit to
- Study type: Interventional · Phase 4
- Participants enrolled: 129
- From 1 Sept 2025 to the primary completion date, 1 Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with concurrent croup.
- Systemic steroid use within the last 8 weeks.
Other illness
- Presence of comorbidities (cardiovascular, neurological, malignancy, chronic kidney or lung disease).
- Failure to obtain informed consent.
Other
- Patients with pneumonia.
- Patients with air leaks (pneumothorax, pneumomediastinum).
- Patients requiring immediate Intensive Care Unit (ICU) admission.
- \-
Who the study is looking for
- History of receiving salbutamol ± steroid treatment for two or more previous wheezing attacks, OR physician-diagnosed asthma.
- Patients admitted to the Pediatric Emergency Department due to severe asthma exacerbation (Pediatric Respiratory Assessment Measure \[PRAM\] score ≥8).
- \-
Age in the registry: 2 years to 18 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.