NCT07731958Recruiting
Unilateral vs. Bilateral Lung Volume Reduction Surgery
Unilateral Versus Bilateral Lung Volume Reduction Surgery for Patients With Severe COPD
Source: ClinicalTrials.gov · Last updated 28 Jul 2026
Brief summary (registry, in English)
This study compares two surgical approaches for patients with severe Chronic Obstructive Pulmonary Disease (COPD) and severe emphysema: unilateral (operating on one lung) versus bilateral (operating on both lungs) lung volume reduction surgery (LVRS).
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 146 (estimated)
- First submitted
- 17 Jul 2026
- Start date
- 21 Mar 2025
- Primary completion date
- Jul 2031
- Lead sponsor
- Copenhagen University Hospital, Rigshospitalet
- Diseases
- COPD
- NCT number
- NCT07731958
What you commit to
- Study type: Interventional
- Planned participants: 146
- From 21 Mar 2025 to the primary completion date, Jul 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Massive adhesions during surgery assessed by the surgeon indicating problems postoperatively
- Perioperative decision on not doing operation on the other side (medical, surgical or anaesthesiologic problems that favours a fast termination of the surgery, decided by the team in OR).
- Previous cardiothoracic surgery
Other illness
- Psychiatric disorder (anxiety, depression, schizophrenia)
- Simultaneous lung cancer surgery
- Increased risk of post-operative bleeding assessed perioperatively by the surgeon.
Lab values
- Increased bleeding risk (e.g., preoperative INR \>2, overdue discontinuation of anticoagulants according to guidelines by the Danish Society for Thrombosis and Haemostasis, known coagulopathy).
Other
- Dependent on wheelchair
- Living in nursery home
- Dependent on walker device
Who the study is looking for
- Suitable target areas in both lungs
- Age ≥ 18 years.
- Speaks and understands Danish or English
- Informed consent obtained
- Usual inclusion criteria in LVRS:
- Moderate to severe COPD with MRC score \> 2 \< 75 years old 17 \< BMI \> 30 FEV1 \> 20% and \< 45% of predicted RV \> 200% of predicted as a sign of relevant hyperinflation DLCO \> 20% of predicted The patient should be in ideal medical treatment and have completed rehabilitation A high-resolution CT \< 3 months old should follow the referral to MDT Absence of nodules suspicious of malignancy on CT scan Absence of significant comorbidity including severe cardiovascular disease LVEF normal Absence of pulmonary hypertension, TI-gradient \< 40 mmHg Absence of chronic or frequent lung infections Smoking abstinence six months prior to surgery Assessed as sufficiently physically fit to undergo surgery and rehabilitation
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rigshospitalet Coordinator of this site? Confirm its status | Copenhagen | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.