NCT07734792Not yet recruitingPhase 2/3
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Effect of Tirzepatide on Functional Outcomes in Patients With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy: A Multicenter, Randomized, Controlled, Blinded Outcome Assessment Trial
Source: ClinicalTrials.gov · Last updated 1 Oct 2026
Brief summary (registry, in English)
Acute ischemic stroke caused by blockage of a large artery in the brain is one of the leading causes of death and long-term disability worldwide. For patients with this type of stroke, endovascular thrombectomy (EVT), a procedure that removes the blood clot and restores blood flow to the brain, has become the standard treatment. However, even when blood flow is successfully restored, many patients continue to experience disability because of ongoing brain injury caused by inflammation, oxidative stress, and damage to brain cells after the stroke. This study aims to evaluate whether tirzepatide, a medication that activates both glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) pathways, can improve recovery in patients with acute ischemic stroke caused by large vessel occlusion who receive thrombectomy. Tirzepatide is currently approved for the treatment of conditions such as type 2 diabetes and obesity. Previous studies have shown that tirzepatide can improve blood sugar control, reduce body weight, and provide beneficial effects on cardiovascular health. Laboratory studies and early clinical evidence suggest that medications targeting GLP-1 and GIP pathways may also have protective effects on the brain by reducing inflammation, protecting brain cells, improving blood vessel function, and supporting recovery after stroke. In this study, eligible patients with acute ischemic stroke caused by blockage of a major brain artery will be randomly assigned to receive either tirzepatide plus standard stroke care or standard stroke care alone. Participants will receive two subcutaneous injections of tirzepatide: the first dose before the thrombectomy procedure and the second dose 7 days after the procedure. The study will include multiple hospitals and will use independent assessment of outcomes to ensure reliable evaluation of treatment effects. The primary purpose of this study is to determine whether early treatment with tirzepatide can improve functional recovery 90 days after stroke, measured by the patient's ability to perform daily activities and live independently. The study will also evaluate whether tirzepatide is safe in patients with acute ischemic stroke by monitoring adverse events, complications, and other clinical outcomes. The findings from this study may provide important evidence for a new treatment approach to improve recovery after thrombectomy and reduce disability among patients with severe ischemic stroke.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2/3
- Study type
- Interventional
- Enrollment
- 726 (estimated)
- First submitted
- 17 Jul 2026
- Start date
- 20 Sept 2026
- Primary completion date
- 31 May 2028
- Lead sponsor
- yifang zhu
- Diseases
- Stroke
- NCT number
- NCT07734792
What you commit to
- Study type: Interventional · Phase 2/3
- Planned participants: 726
- From 20 Sept 2026 to the primary completion date, 31 May 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receipt of intravenous thrombolysis prior to randomization;
- Simultaneous bilateral anterior-circulation occlusions or concurrent anterior- and posterior-circulation occlusions;
- Active bleeding within the previous month (e.g., gastrointestinal, genitourinary, or retinal hemorrhage), major organ surgery or biopsy within 14 days before stroke onset, or known bleeding diathesis;
- Previous use of GLP-1 receptor agonists or GIP receptor agonists, or known hypersensitivity to these agents;
- History of severe anxiety or depression prior to stroke onset;
Other illness
- Posterior-circulation large vessel occlusion stroke;
- Intracranial hemorrhage on baseline CT or MRI, including subarachnoid hemorrhage or intracerebral hemorrhage; evidence of large established infarction, defined as:
- ASPECTS \<6,
- Ischemic core volume ≥70 mL on CTP, or
- Infarction involving \>1/3 of the middle cerebral artery territory;
- Refractory hypertension despite treatment, defined as persistent systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg;
- Personal or family history of medullary thyroid carcinoma (MTC) or diagnosis of Multiple Endocrine Neoplasia Type 2 (MEN2);
- Severe underlying disease with life expectancy \<1 year, such as advanced malignancy;
Lab values
- Severe hepatic or renal impairment, including:
- Estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 m²,
- Serum creatinine \>200 μmol/L,
- Child-Pugh Class C or higher liver disease,
- Recurrent unexplained hypoglycemia;
- Blood glucose \<2.7 mmol/L or \>22.2 mmol/L; platelet count \<80 × 10⁹/L; or international normalized ratio (INR) \>1.7;
Other
- Participants meeting any of the following criteria will be excluded:
- Pregnancy or breastfeeding;
- Participation in another clinical trial.
Who the study is looking for
- Participants must meet all of the following criteria:
- Age \>18 years and ≤80 years;
- Acute ischemic stroke with imaging-confirmed anterior large vessel occlusion at:
- Terminal ICA,
- M1 segment of the middle cerebral artery, or
- Dominant M2 segment;
- NIHSS score between 6 and 25 prior to randomization;
- Alberta Stroke Program Early CT Score (ASPECTS) of 6-10 before randomization;
- Time from symptom onset (or last known well) to planned endovascular thrombectomy within 24 hours;
- Pre-stroke mRS score of 0-1;
- Patients presenting within 6 hours of symptom onset are eligible for direct EVT. Patients presenting between 6 and 24 hours after symptom onset must undergo advanced imaging demonstrating a salvageable perfusion mismatch and meet the DEFUSE-3 criteria: an infarct core volume \<70 mL, a mismatch volume \>15 mL, and a mismatch ratio \>1.8;
- Written informed consent provided by the participant or a legally authorized representative.
Age in the registry: 19 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Second Afliated Hospital of SooChow University Coordinator of this site? Confirm its status | Suzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.