Positron Emission Tomography/Computed Tomography (PET/CT) Imaging in Patients Diagnosed With a Glioma

Other illness

• Active connective tissue disorders, such as lupus or scleroderma.
• History of allergic reaction to minocycline or any tetracyclines.
• History of colitis during antibiotics treatment.

Lab values

• Patients who are pregnant or lactating are excluded. Premenopausal women (defined per institutional guidelines) must have a negative pregnancy test (urine or serum) within 7 days of the PET scan.
• Ongoing treatment with warfarin with INR \> 1.5.

Other

• Severe increased intracranial pressure, status epilepticus, or other severe or progressing clinical symptoms requiring urgent intervention in the opinion of the treating
• Karnofsky performance score \<60, as determined by one of the clinician co- investigators.
  • ADDITIONAL CRITERIA FOR ARM 1:

• Age =18 years.
• Patient is able to lie in the PET/CT scanner for at least 60 minutes while undergoing scanning.
• Patient is willing and able to review, understand, and provide written consent for the study procedures and indicates that they are aware of the investigational nature of this study.
• Histopathology/cytopathological diagnosis of a glioblastoma without a history of radiation.
• The tumor is deemed amenable for radiation treatment (pre-radiation planning MRI can be done before or after the PET scan).
  • ADDITIONAL CRITERIA FOR ARM 2:
• Previous histopathology/cytopathological diagnosis of glioblastoma.
• History of glioma radiation.
• Presence of a new or progressing enhancing brain lesion on follow-up clinical MRI suspicious for post-radiation glioma progression or late radiation-induced MRI changes (i.e., radiation injury), at least 7 mm in bidirectional diameter.
• The most recent MRI, used for comparison with the PET/CT, is performed within 4 weeks of the planned PET scan.
  • ADDITIONAL CRITERIA FOR ARM 3
• MRI diagnosis of a brain tumor, previously verified to be a low-grade (WHO grade 2, IDH (isocitrate dehydrogenase) mutant glioma, based on histopathology from biopsy or resection.
• The detected mass on the most recent clinical MRI is at least 7 mm in bidirectional diameter (i.e., twice the PET scanner resolution).
• The tumor does not require urgent (within 1 month) resection, steroid treatment, or radiation.
• The most recent MRI, used for comparison with the PET/CT, is performed within 4 weeks.
• Patient agrees to have a baseline and follow-up PET/CT scan (approximately 1 month later) and interval oral treatment with 200mg/day minocycline.
• Due to planned minocycline treatment, patients will need to have adequate renal function

Criteria the registry did not label

• FOR ARMS 1-3