Weight Loss and Hunger

Prior treatment

• currently use antidepressants, thyroid medication, or any medication that could affect appetite;
• currently taking monoamine oxidase inhibitors, pressor agents, warfarin, anticonvulsants, phenylbutazone, or tricyclic antidepressants;

Other illness

• have a current diagnosis of an axis 1 psychiatric disorder (i.e. mood, anxiety and eating disorders);
• have a history of cardiac problems or symptoms suggestive of any cardiac condition;
• have uncontrolled thyroid disease;
• have any osteoarticular condition, or other reasons that would prevent them from achieving the proposed walking targets.
  • In addition, Females will be excluded if they:

Lab values

• have a current diagnosis or history of diabetes, confirmed by a measure of HbA1c during the screening visit;

Other

• have alcohol intake that exceeds recommendations or alcoholism, or current addictions to opiates, cocaine or stimulants;
• are pregnant or planning to become pregnant over the course of the study;
• are peri- or post-menopausal or have had surgically induced menopause.

• 18-55 years of age;
• non-smoking;
• obese class I-II (30 kg/m2 ≤ BMI \< 40 kg/m2);
• weight stable (± 2 kg during the 6 months prior to enrollment);
• Sedentary (\<2 times/week of 30 min of continuous exercise)
  • In addition, Females will be included if:
  • 1\) premenopausal (2 menses in the 3 months preceding testing, no increase in cycle irregularity in the 12 months preceding testing).