NCT07741266Not yet recruiting
Effects of a Large Language Model-Driven Chatbot on Reproductive Concerns After Cancer
The Feasibility and Preliminary Effectiveness of a Large Language Model-Driven Chatbot in Addressing Reproductive Concerns Among Adolescent and Young Adult Cancer Survivors: A Pilot Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 3 Aug 2026
Brief summary (registry, in English)
Reproductive health has emerged as a critical yet overlooked concern among Adolescent and Young Adult (AYA) cancer survivors, given their compromised potential for biological parenthood in prime childbearing years. Large language models (LLMs) offer a promising solution to bridge onco-fertility service gaps by integrating evidence-based knowledge and therapeutic frameworks. This pilot randomized controlled trial aims to assess the feasibility and preliminary effectiveness of an LLM-driven chatbot versus electronic brochure in addressing reproductive concerns among AYA cancer survivors.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 28 Jul 2026
- Start date
- 1 Sept 2026
- Primary completion date
- 30 Jun 2027
- Lead sponsor
- The Hong Kong Polytechnic University
- Diseases
- Childhood cancers
- NCT number
- NCT07741266
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Sept 2026 to the primary completion date, 30 Jun 2027
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- (1) Involvement in the chatbot co-design phases; (2) inability to provide informed consent; (3) significant sensory, cognitive, or psychological impairments precluding meaningful participation; and (4) acute illness at the time of recruitment.
Who the study is looking for
- (1) 15-39-year-old females; (2) cancer diagnosis between ages 15-39; (3) current or prior concerns regarding fertility; (4) proficiency in Mandarin Chinese; and (5) access to a mobile device for intervention delivery.
Age in the registry: 15 years to 39 years · Sex: Female · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Science and Technology of China Coordinator of this site? Confirm its status | Hefei | China | Unknown status |
| The Hong Kong Polytechnic University Coordinator of this site? Confirm its status | Kowloon | Hong Kong SAR China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.