NCT07741305Recruiting
Comparison of Three-dimensional and Two-dimensional Left Ventricle Strain With Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction
Left Ventricular Myocardial Strain Assessed by Three-dimensional Speckle-tracking Echocardiography in Heart Failure With Reduced and Mildly Reduced Ejection Fraction. A Comparison With Two-dimensional Evaluation in a Prospective Study
Source: ClinicalTrials.gov · Last updated 19 Aug 2026
Brief summary (registry, in English)
This study will compare two ultrasound techniques, 2D and 3D speckle-tracking echocardiography, for measuring how well the heart muscle contracts in patients with heart failure and reduced pumping function. While 2D global longitudinal strain (GLS) is widely used and has proven value in predicting outcomes, 3D GLS may provide a more complete assessment of heart function. Researchers will enroll 419 patients from seven cardiac rehabilitation hospitals in Italy and analyze heart ultrasound images using standardized equipment and software. The study will assess how closely 2D and 3D GLS measurements agree, identify factors that influence any differences, and determine whether 3D GLS better predicts the risk of death than 2D GLS.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 419 (estimated)
- First submitted
- 28 Jul 2026
- Start date
- 8 Jan 2026
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Istituti Clinici Scientifici Maugeri SpA
- Diseases
- Heart failure
- NCT number
- NCT07741305
What you commit to
- Study type: Observational
- Planned participants: 419
- From 8 Jan 2026 to the primary completion date, 31 Dec 2027
- 5 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Arrhythmias that make multi-beat acquisition impossible (if required), such as frequent extrasystoles (supraventricular or ventricular) and atrial fibrillation;
- Failure to visualize more than 2 segments of the left ventricle (LV), or inability to assess more than 3 segments during 3D GLS analysis;
- Failure to sign the informed consent form and inability of the participant to understand the objectives of the study
Other
- Inability to maintain the correct position for acquiring echocardiographic images;
Who the study is looking for
- Left ventricular ejection fraction (LVEF) ≤ 49%;
- Echocardiographic image quality judged to be at least adequate according to a four-point visual image quality scale (good, adequate, poor, or inadequate)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (5)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ICS Maugeri - Istituto di Bari Coordinator of this site? Confirm its status | Bari | Italy | Recruiting |
| ICS Maugeri - Istituto di Milano Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| ICS Maugeri - Istituto di Pavia Coordinator of this site? Confirm its status | Pavia | Italy | Recruiting |
| ICS Maugeri Torino Coordinator of this site? Confirm its status | Torino | Italy | Recruiting |
| ICS Maugeri - Istituto di Veruno Coordinator of this site? Confirm its status | Veruno | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.