NCT07741968Recruiting
A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer
An e-Health Intervention for Fear of Progression in Women With Gynecologic or Breast Cancer
Source: ClinicalTrials.gov · Last updated 16 Oct 2026
Brief summary (registry, in English)
This clinical trial studies whether an intervention supported by technology (blended e-health intervention) works to improve fear of progression (FOP) in women with gynecologic or breast cancer. FOP is the fear patients experience from the possibility that their cancer could grow, spread, or get worse. Managing FOP is a leading unmet concern of cancer patients. High levels of FOP are associated with distress, depression, and increased health care costs, despite this, access to resources to address FOP remain limited. The blended e-health intervention in this trial offers remote group sessions along with online sessions to help patients access the information. Session content incorporates values-based goal setting and skills practices to manage unhelpful beliefs about worry and promote helpful coping behaviors. The sessions may help patients recognize unhelpful thoughts and behaviors which reinforce worry. A blended e-health intervention may be an effective way to improve FOP in women with gynecologic or breast cancer.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 126 (estimated)
- First submitted
- 10 Jun 2026
- Start date
- 9 Sept 2026
- Primary completion date
- 6 Aug 2028
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Triple-negative breast cancer, Endometrial cancer, Cervical cancer, Metastatic breast cancer, Ovarian cancer
- NCT number
- NCT07741968
What you commit to
- Study type: Interventional
- Planned participants: 126
- From 9 Sept 2026 to the primary completion date, 6 Aug 2028
- 11 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Ongoing uncontrolled active psychiatric condition that, in the opinion of the investigator, would interfere in the conduct of the study (e.g., mood disorders, psychosis disorders, or substance use), Major depression as assessed by Patient Health Questionnaire-9 (PHQ-9)
Other
- Enrolled in hospice
- Non-English speaking
- Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics)
- Current participation in a mind-body or mindfulness education program within the past six weeks
Who the study is looking for
- Women with stage III or IV GYN (ovarian, endometrial, cervical, vulvar/vaginal) or breast cancer who are at least 2 months from initial diagnosis OR Women with stage I or II endometrial, ovarian, or breast cancer with carcinosarcoma histology OR Women with stage I or II triple negative breast cancer
- Score ≥ 34 on the Fear of Progression Short-Form, indicating dysfunctional levels
- Age 18 or older; able to read and understand English
- Patients can be on active treatment or surveillance. They can be no evidence of disease (NED), recurrent or with progressive disease
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (11)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope at Arcadia Coordinator of this site? Confirm its status | Arcadia | United States | Recruiting |
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
| City of Hope at Seacliff Coordinator of this site? Confirm its status | Huntington Beach | United States | Recruiting |
| City of Hope at Irvine Lennar Coordinator of this site? Confirm its status | Irvine | United States | Recruiting |
| City of Hope Antelope Valley Coordinator of this site? Confirm its status | Lancaster | United States | Recruiting |
| City of Hope at Long Beach Elm Coordinator of this site? Confirm its status | Long Beach | United States | Recruiting |
| City of Hope at Santa Clarita Coordinator of this site? Confirm its status | Santa Clarita | United States | Recruiting |
| City of Hope at Simi Valley Coordinator of this site? Confirm its status | Simi Valley | United States | Recruiting |
| City of Hope at South Pasadena Coordinator of this site? Confirm its status | South Pasadena | United States | Recruiting |
| City of Hope at Upland Coordinator of this site? Confirm its status | Upland | United States | Recruiting |
| City of Hope at West Covina Coordinator of this site? Confirm its status | West Covina | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.