NCT07742709Active, not recruiting
Study on the Rapid Diagnostic Value of Sudden Clap Provocation Test in Psychogenic Nonepileptic Seizures
Clinical Utility of the Abrupt Clap Provocation Test for Rapid Differentiation of Psychogenic Non-Epileptic Seizures From Epileptic Seizures
Source: ClinicalTrials.gov · Last updated 3 Aug 2026
Brief summary (registry, in English)
To explore the clinical value of the sudden clap provocation test in the differential diagnosis between epileptic seizures and psychogenic non-epileptic seizures, so as to provide a new strategy for rapid, low-cost differential diagnosis. This study is a prospective, single-center, diagnostic trial. This study is a single-center, prospective study that plans to recruit 400 patients who have "convulsive seizure" events during video electroencephalogram monitoring. A standardized sudden clap test is adopted, and one sudden clap test is performed during each clinically detected seizure episode, with the study period covering the entire VEEG monitoring process (approximately 24 hours). During the trial, the patient's basic treatment plan and VEEG monitoring process remain unchanged, and data analysis and diagnostic efficacy evaluation will be carried out after the VEEG monitoring is completed.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 1000 (estimated)
- First submitted
- 19 Jul 2026
- Start date
- 1 Feb 2026
- Primary completion date
- Aug 2026
- Lead sponsor
- Xijing Hospital
- Diseases
- Epilepsy
- NCT number
- NCT07742709
What you commit to
- Study type: Observational
- Planned participants: 1000
- From 1 Feb 2026 to the primary completion date, Aug 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Coexisting severe hearing impairment or documented ear disease, rendering the patient unable to effectively perceive normal auditory stimuli
- Episodes definitively diagnosed as other non-epileptic paroxysmal disorders (such as syncope, paroxysmal kinesigenic dyskinesia, or sleep disorders)
Other
- Episodes occurring out of the camera view, obscured, or recorded with poor video quality, preventing accurate assessment of ictal behavioral responses to the clap stimulus
- Severe lack of clinical data, loss to follow-up, or refusal/withdrawal of informed consent
Who the study is looking for
- Continuous video-electroencephalogram (VEEG) monitoring duration of 24 hours or longer
- At least one recorded episode during VEEG monitoring with prominent abnormal limb movements (such as convulsive episodes)
- Successful administration of the standardized Abrupt Clap Provocation Test (ACPT) during the clinical ictal phase
- Episodes definitively diagnosed as epileptic seizures (ES) or confirmed as psychogenic non-epileptic seizures (PNES) at the highest certainty level (Level 4: documented/confirmed) according to the International League Against Epilepsy (ILAE) criteria
- Complete clinical and demographic data available
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Air Force Medical University (Xijing Hospital) Coordinator of this site? Confirm its status | Shanxi | China | Unknown status |
| No.127 Changle West Road, Xincheng District, Xi'an, Shaanxi 710048, China Coordinator of this site? Confirm its status | Shanxi | China | Unknown status |
| The First Affiliated Hospital of Air Force Medical University (Xijing Hospital) Coordinator of this site? Confirm its status | Xian | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.