NCT07743125Completed
Patient-Executed, Clinician-Confirmed Diuretic Titration in Pulmonary Artery Pressure-Guided Heart Failure (SURPASS-HF)
SURPASS-HF: Safety and Utility of Remote Pulmonary Artery Sensor Shared-management in Heart Failure
Source: ClinicalTrials.gov · Last updated 3 Aug 2026
Brief summary (registry, in English)
SURPASS-HF was a 90-day, single-center, single-arm, prospective feasibility study asking whether adults with heart failure and an implanted pulmonary artery (PA) pressure sensor can safely share in managing their own diuretic (water pill) dosing. Participants were already implanted with a CardioMEMS PA pressure sensor and managed by a single cardiovascular team using a previously published hemodynamic treatment algorithm. Each participant received a simplified treatment guide (sliding scale) prescribing how to adjust diuretic doses based on their own PA pressure readings, which were relayed to them daily through the Epic MyChart patient portal. Protocol-mandated laboratory testing followed each diuretic adjustment. The study measured safety (hospitalizations, urgent visits, kidney injury, syncope, electrolyte disturbances) and effectiveness (heart failure hospitalizations, average PA diastolic pressure, and how often the care team needed to intervene) over 90 days, with quality of life assessed by the Minnesota Heart Failure Questionnaire. A separate retrospective chart-review cohort of 31 CardioMEMS patients served as a comparison group.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 21 (actual)
- First submitted
- 29 Jul 2026
- Start date
- 14 Jan 2026
- Primary completion date
- 14 Apr 2026
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- Heart failure
- NCT number
- NCT07743125
What you commit to
- Study type: Interventional
- Participants enrolled: 21
- From 14 Jan 2026 to the primary completion date, 14 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Transplant organ recipient
- Chronic immunosuppressant therapy
- Currently undergoing chemotherapy for malignancy or having received chemotherapeutic treatment in the past 12 months.
- Hospice plan of care or prior designation of hospice plan of care within 12 months.
- Blister packaged medications
Other illness
- Allergy/intolerance to loop or thiazide diuretics.
- Chronic kidney disease Stage IV, V, or undergoing renal replacement therapy.
- Advanced heart failure designation with or without durable mechanical circulatory support.
Other
- Oliguria/anuria either acute or chronic.
- Idiopathic fluid collections (for example ascites, pulmonary or pericardial effusions)
- Technically or medically illiterate precluding use of Epic MyChart application.
- Resident of group/assisted living facility.
- Either partially or completely dependent on social/family support for IADLs/ADLs
Who the study is looking for
- Currently implanted with and actively transmitting remote pulmonary artery pressures using the CardioMEMS HF system and exclusively managed by the Froedtert Menomonee Falls Cardiovascular Team according to previously published hemodynamic treatment algorithm.
- Provision of signed and dated informed consent
- Stated willingness to comply with study procedure and mandates and remain available for the duration of the study period of 90 days.
- Males and females; Ages 40-90
- Documented diagnosis of heart failure (regardless of ejection fraction) with volume related symptoms managed with a loop diuretic.
- Willingness to participate in a shared-management strategy
- Access to necessary resources for participating in a technology-based intervention (i.e., Epic MyChart via computer, smartphone, or tablet with internet access)
Age in the registry: 40 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Froedtert Menomonee Falls Hospital Coordinator of this site? Confirm its status | Menomonee Falls | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.