NCT07743619Not yet recruiting
Rapid Cool: Heat Stroke Treatment
Source: ClinicalTrials.gov · Last updated 3 Nov 2026
Brief summary (registry, in English)
Hot climates such as in Phoenix, AZ commonly have individuals experiencing heat stroke, a life-threatening medical emergency. The dangerously high body temperature can result in death if not treated immediately with rapid body cooling. Rapid core temperature reduction within 30 min of diagnosis results in 100% survival and positive outcomes. While this is easily achieved with whole-body cold water immersion, this modality is not feasible in an ambulance. The Phoenix emergency medical services protocol consists of lying the patient on a large volume of ice. While this is somewhat effective, this cooling strategy results in a sub-optimal cooling rate, difficulty obtaining this large volume of ice, and a very wet ambulance as the ice melts. Recently, a company created a cooling strategy that utilizes a small amount of ice and a small amount of recirculated water to keep the patient cool. The purpose of this study is to determine the core temperature cooling rate of this cooling strategy and compare it to the cooling rate of the currently used Phoenix protocol.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 30 Jul 2026
- Start date
- 21 Nov 2026
- Primary completion date
- 31 Aug 2027
- Lead sponsor
- State University of New York at Buffalo
- Diseases
- Stroke
- NCT number
- NCT07743619
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 21 Nov 2026 to the primary completion date, 31 Aug 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- If taking a psychiatric medication, the dosage has changed within the month prior to first study visit
- Cannot abstain from taking over-the-counter medications or supplements for 24 hours before study visits (with exception of vitamins)
- Has taken antibiotics or corticosteroids within 4 weeks of enrollment
- Has a medical implant device such as a pacemaker, patient monitoring system, or metallic implant
Other illness
- History of cardiovascular, neurological, metabolic, pulmonary, renal, gastrointestinal, or autoimmune disease
- Taking prescription medication (with exception of psychiatric medication)
- Resting heart rate of ≥100 beats per minute
- Musculoskeletal injury/condition that negatively impacts the protocol
- History of heat illness that resulted in a visit to a medical center in the past 2 years
- Study physician or PI discretion based on any other medical condition or medication
Other
- Resting systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥90 mmHg
- Regular smoker of cigarettes or has regularly smoked in the past year
- Has donated blood or plasma in the past 3 months
- Has a full or partially amputated limb
- Pregnant or breastfeeding
Who the study is looking for
- Adult participant (18 - 39 years old)
- Body mass index (BMI) 18 - 30 kg/m2
- At least moderate intensity aerobic exercise ≥60 min per week
- Participant is able and willing to follow study procedures
Age in the registry: 18 years to 39 years · Sex: All · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.