NCT07743645Recruiting
Developing Biomarker-Supported Schizophrenia Spectrum Disorder (SSD) Prevention
Developing Biomarker-Supported SSD Prevention
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to compare the effect of a brief family-based psychosocial intervention that addresses modifiable SSD risk factors on persistent and distressing psychotic-like experiences in children and young adults with a family history of SSD and high versus low baseline SSD-like brain patterns
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 30 Jul 2026
- Start date
- Sept 2026
- Primary completion date
- Apr 2031
- Lead sponsor
- The University of Texas Health Science Center, Houston
- Diseases
- Schizophrenia
- NCT number
- NCT07743645
What you commit to
- Study type: Interventional
- Planned participants: 100
- From Sept 2026 to the primary completion date, Apr 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- current drug or alcohol use that impacts functioning and study engagement;
Other illness
- Current or past history of psychotic disorders or clinical high risk for psychosis (CHR-p) per study interview;
- Current or past antipsychotic medication use to specifically treat a psychotic disorder;
- major medical and neurological conditions;
Other
- moderate to severe intellectual disabilities or mild intellectual disabilities but expected to have difficulty completing the study assessments;
- Not able to give assent, permission, or consent;
- Not able to undergo MRI.
Who the study is looking for
- Family history of SSD (defined as first-degree (e.g., a parent or a sibling), second-degree (e.g., an uncle or a grandparent), or other combinations of biological relatives in the family have or likely have a diagnosis of SSD or other closely related severe mental illnesses equivalent to at least 25% of genetic sharing) per medical record review and/or parent/legal guardian/self report and confirmed by a structured interview;
- screening positive for two or more risk factors targeted by the intervention;
- aged ≥ 9 and \<26 years of birthday;
- Participants and parent(s)/legal guardian(s)/other family member(s) agree to participate;
- psychiatrically stable and have no major changes in antidepressant, stimulant, or antipsychotic medication in the past 4 weeks.
Age in the registry: 9 years to 26 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The University of Texas Health Science Center at Houston Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.