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NCT07744958Not yet recruiting

RESTORE-BLADDER (REgistry on STrategies for Organ pREservation in Muscle-invasive BLADDER Cancer)

Source: ClinicalTrials.gov · Last updated 4 Aug 2026

Brief summary (registry, in English)

Removal of the urinary bladder (radical cystectomy) is a major surgical procedure that can have a permanent impact on a patient's quality of life. Consequently, some patients, despite having received comprehensive counseling and completing systemic therapy, decide against subsequent surgery or alternative radiotherapy. Recent scientific studies suggest that, for selected patients, an attempt at bladder preservation may be a medically justifiable option. However, it remains unclear which patients are truly suitable candidates for bladder-preserving management and which are not. The aim of this registry is therefore to collect and analyze clinical data from this specific patient population.

Status (registry)
Not yet recruiting
Study type
Observational
Enrollment
100 (estimated)
First submitted
30 Jul 2026
Start date
Sept 2026
Primary completion date
Feb 2029
Lead sponsor
Heinrich-Heine University, Duesseldorf
NCT number
NCT07744958

What you commit to

  • Study type: Observational
  • Planned participants: 100
  • From Sept 2026 to the primary completion date, Feb 2029
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • No prior preoperative systemic therapy

Age

  • Age \< 18 years

Other

  • Lack of capacity to provide informed consent
  • No histological confirmed muscle-invasive urothelial carcinoma

Who the study is looking for

  • Patients aged \>= 18 years, capable of providing informed consent
  • Histologically confirmed muscle-invasive urothelial carcinoma of the urinary bladder
  • Received perioperative systemic therapy in accordance with current guidelines and subsequently decline cystectomy or radiotherapy

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.