NCT07745699Completed
Fully Remote, Telehealth-based Ketogenic Metabolic Therapy for Long COVID
A National, Fully Decentralized, Telehealth-Based Ketogenic Metabolic Therapy Intervention for Individuals With Long COVID: A 12-Week, Single-Arm Feasibility and Acceptability Trial Targeting ME/CFS and POTS Phenotypes
Source: ClinicalTrials.gov · Last updated 6 Aug 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if a 12-week ketogenic diet program combined with lifestyle strategies (called KMT-LS) is practical and acceptable as a fully remote intervention for adults with Long COVID who also have Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (ME/CFS) and dysautonomia (problems with heart rate, blood pressure, or other automatic body functions). The main questions it aims to answer are: Can a ketogenic diet program be successfully delivered entirely from home using online tools and virtual support? Do participants stay in the study, follow the diet, and find the program safe and satisfactory? Do participants experience improvements in fatigue, sleep, mood, daily functioning, and symptom flare-ups after exertion? Participants will: Follow a ketogenic diet for 12 weeks with weekly virtual nutrition support sessions Use at-home tools to track their ketone levels and confirm they are following the diet Complete online questionnaires about their symptoms, energy, sleep, mood, and daily functioning at the start of the study, after 12 weeks, and again 3 months later.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 11 (actual)
- First submitted
- 29 Jul 2026
- Start date
- 10 Dec 2024
- Primary completion date
- 1 Jun 2025
- Lead sponsor
- National University of Natural Medicine
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT07745699
What you commit to
- Study type: Interventional
- Participants enrolled: 11
- From 10 Dec 2024 to the primary completion date, 1 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Known pregnancy or planning pregnancy during the study period
- Active cancer diagnosis
- Renal or liver failure
- Pancreatitis
- Atrial fibrillation or significant cardiac arrhythmia
- Significant atherosclerotic disease
- Uncontrolled hypertension or hypertriglyceridemia
- Active or recent thrombosis
- Use of antiepileptic medications
- Use of SGLT-2 inhibitors
- Substance use disorder
- Type I diabetes
- History of inborn errors of metabolism
- Previous completion of a nutritional and lifestyle program for this condition
Who the study is looking for
- Age 18 years or older
- English-speaking
- Suspected, probable, or confirmed SARS-CoV-2 infection as defined by the Pan American Health Organization
- Long COVID diagnosed via structured clinical interview, consistent with the World Health Organization clinical case definition and the National Academies of Sciences, Engineering, and Medicine (2024) definition
- Physician-confirmed diagnosis of post-infectious dysautonomia and ME/CFS; OR self-reported dysautonomia symptoms with a Malmö POTS Score Assessment (MAPS) score greater than 40
- Met the National Academy of Medicine diagnostic criteria for ME/CFS
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| National University of Natural Medicine Coordinator of this site? Confirm its status | Portland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.