NCT07745803Not yet recruiting
Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma
Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma: A Multi-Disease Cohort Study
Source: ClinicalTrials.gov · Last updated 4 Aug 2026
Brief summary (registry, in English)
The goal of this observational study is to develop better ways to detect and predict major oral diseases, including oral cancer, gum disease, and tooth decay. This study will collect detailed oral health information and biological samples from adults with different oral health conditions and healthy participants to identify markers that may help doctors detect diseases earlier and predict how diseases may change over time. The main questions this study aims to answer are whether biological markers from saliva, mouth rinse samples, blood, or oral tissue samples can help identify people with oral diseases, whether these markers can predict future disease changes such as worsening gum disease, new or progressing tooth decay, or recurrence and spread of oral cancer, and whether combining clinical information with biological markers can improve disease detection and risk prediction. Participants will receive a standard oral health examination, provide information about their health history and oral health behaviors, provide biological samples when appropriate, and be followed over time through clinical visits, questionnaires, and health information collection. Researchers will compare findings among people with different oral health conditions and healthy participants to better understand disease-related changes and develop tools for earlier detection and prediction of oral disease outcomes.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 4000 (estimated)
- First submitted
- 13 Jul 2026
- Start date
- 25 Aug 2026
- Primary completion date
- 30 Dec 2027
- Lead sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
- Diseases
- Head and neck cancer
- NCT number
- NCT07745803
What you commit to
- Study type: Observational
- Planned participants: 4000
- From 25 Aug 2026 to the primary completion date, 30 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of radiotherapy to the head and neck region.
- Presence of immunodeficiency conditions (for example, human immunodeficiency virus infection).
Other
- Participants will be excluded if they meet any of the following criteria:
- Edentulous individuals.
- Pregnancy.
Who the study is looking for
- Participants must meet all of the following criteria:
- Adults aged 18 years or older.
- Able to understand the study information and provide written informed consent.
- Meet the criteria for one of the study groups based on clinical evaluation and disease assessment, including:
- Oral squamous cell carcinoma (OSCC); Periodontal disease; Dental caries; Oral health without the corresponding diseases (healthy controls).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.