NCT07746310Completed
Dietary Nitrate and Nitrite Intake and Phosphate Biomarkers and Risk of Chronic Diseases
Nitrate, Nitrite and Phosphate and the Public Health - The Good and the Bad of Natural Components Ubiquitously Found in Our in Food and Drinking Water
Source: ClinicalTrials.gov · Last updated 5 Aug 2026
Brief summary (registry, in English)
Nitrate, nitrite, and phosphate (NO3, NO2, P) are at all age stages ubiquitous in our everyday foods, including naturally occurring and as food additives, and in our drinking water. These compounds are essential in maintaining human well-being and health, but they have also been linked to detrimental health effects including contribution to cancer initiation and artery calcification, making it difficult to evaluate their overall health impact. Therefore, the overarching aim of this project is to shed light on the potential dual effect of these compounds on a variety of chronic diseases (cardiovascular and respiratory diseases, gastrointestinal cancers) at different life stages and to further elucidate on the molecular mechanisms suggested to underly the pathogenesis of these disease outcomes. This will be achieved by using prospective, longitudinal population-based cohorts linked to comprehensive databases of NO3 and NO2 and using a biomarker of P while also integrating omics data on inflammatory and cardiometabolic biomarkers as well as the microbiome and urine bacterial metabolites. The project will be led by the PI and conducted by a team of PhD students and postdoc in close collaboration with relevant experts. It will be initiated early on and continued throughout a 4-year study period. With this research, the investigators attempt to provide the strongest scientific evidence with etiologically more relevant exposure-disease associations and to shape future health risk assessments.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 86000 (actual)
- First submitted
- 28 Jul 2026
- Start date
- 1 Jan 1987
- Primary completion date
- 31 Dec 2024
- Lead sponsor
- Karolinska Institutet
- Diseases
- Asthma, Childhood cancers
- NCT number
- NCT07746310
What you commit to
- Study type: Observational
- Participants enrolled: 86000
- From 1 Jan 1987 to the primary completion date, 31 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Prevalent disease at baseline (depending on research question)
Other
- SMC and COSM
- Incorrect or missing national registration number
- Implausible energy intake
- BAMSE cohort
- The family planned to move within 1 year of the study start;
- Insufficient knowledge of the Swedish language;
- The family had a seriously ill child or
- an older sister or brother was already included in the study.
Who the study is looking for
- SMC and COSM
- Born between 1914 and 1948 (SMC) or through 1952 (COSM)
- Residing in Västmanland and Uppsala counties (SMC)
- Residing in Västmanland and Örebro counties (COSM)
- BAMSE cohort
- All children born in certain areas of northern and central Stockholm between Feb 1994 and Nov 1996.
Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Karolinska Institutet Coordinator of this site? Confirm its status | Stockholm | Sweden | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.