NCT07748598Recruiting
HER2+ CNS Surveillance
HER2-CNS SURVEILLANCE: A Study of the Feasibility of Randomising Women and Men With HER2 Positive Metastatic Breast Cancer to Central Nervous System Surveillance Versus no Surveillance
Source: ClinicalTrials.gov · Last updated 5 Aug 2026
Brief summary (registry, in English)
A multi-centre, randomised study, to determine the feasibility of recruiting men and women with metastatic HER2 positive breast cancer to a study with a baseline MRI scan followed by randomising to surveillance by two further six-monthly MRI scans versus no further surveillance of the brain. Qualitative research (focus groups and/or interviews) and monitoring of approach and consent with SEAR framework will be embedded within the trial to achieve the primary endpoint and explore challenges with study implementation and delivery.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 69 (estimated)
- First submitted
- 27 Jul 2026
- Start date
- 3 Oct 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
- NCT number
- NCT07748598
What you commit to
- Study type: Interventional
- Planned participants: 69
- From 3 Oct 2025 to the primary completion date, 31 Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Inability to provide informed consent.
Who the study is looking for
- Estrogen receptor (ER) positive or negative disease. Visceral disease present. Receiving active HER2-directed therapy. ECOG Performance Status 0-2. Life expectancy greater than 6 months. Written informed consent and ability to comply with study procedures and follow-up.
Age in the registry: 16 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Clatterbridge Cancer Centre NHS Foundation Trust Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.