NCT07749170Recruiting
FORWARD: Functional Outcomes in Real-World Treatment And Revascularization of Non-dominant and Distal M2 Occlusions
Source: ClinicalTrials.gov · Last updated 29 Oct 2026
Brief summary (registry, in English)
The objective of this study is to collect safety and effectiveness data on the Penumbra System reperfusion catheters in participants with isolated primary non-dominant and distal M2 occlusions who undergo endovascular mechanical thrombectomy (EVT). Additionally, this study aims to observe characteristics and outcomes of participants treated with medical management (MM) alone and those who receive EVT + MM per current medical practice.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 250 (estimated)
- First submitted
- 8 Jul 2026
- Start date
- 26 Jun 2026
- Primary completion date
- Sept 2028
- Lead sponsor
- Penumbra Inc.
- Diseases
- Stroke
- NCT number
- NCT07749170
What you commit to
- Study type: Observational
- Planned participants: 250
- From 26 Jun 2026 to the primary completion date, Sept 2028
- 7 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently participating in an investigational (drug, device, etc.) clinical trial that will influence the endovascular procedure or acute treatment. Participants in secondary prevention, observational, natural history and/or epidemiological studies are eligible.
Other illness
- Current hospitalization at time of stroke onset and/or any comorbid disease or condition expected to compromise survival or ability to complete follow-up assessments through 90 days
- Other medical, behavioral, or psychological conditions that in the opinion of the Investigator could limit the ability to participate in the study, including compliance with follow-up requirements, or that could impact the scientific integrity of the study
Other
- Any stenosis or occlusion in the ICA origin requiring treatment during the procedure or within the 90-day follow-up period.
- Known multiple occlusions
- Secondary M2 occlusion
- Known or high suspicion of underlying ICAD as the cause of the M2 occlusion
Who the study is looking for
- Participant age ≥ 18
- Participant experiencing acute ischemic stroke due to a confirmed primary M2 occlusion in the vertical segment or post-bifurcation in the non-dominant or co-dominant branch of the horizontal segment
- NIHSS ≥5 or NIHSS 3-4 with disabling symptoms
- Pre-stroke mRS 0-1
- For participants undergoing thrombectomy: Planned first-line treatment with Penumbra System reperfusion catheters
- Informed consent obtained per Institutional Review Board/Ethics Committee requirements
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (7)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Medical University of South Carolina (MUSC) Coordinator of this site? Confirm its status | Charleston | United States | Recruiting |
| Swedish Medical Center Coordinator of this site? Confirm its status | Englewood | United States | Recruiting |
| Fort Sanders Regional Medical Center Coordinator of this site? Confirm its status | Knoxville | United States | Recruiting |
| University of Kentucky Coordinator of this site? Confirm its status | Lexington | United States | Recruiting |
| Semmes Murphey Coordinator of this site? Confirm its status | Memphis | United States | Recruiting |
| Yale New Haven Hospital Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
| Wellspan York Hospital Coordinator of this site? Confirm its status | York | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.