NCT07751263Not yet recruiting
15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis
15-Hydroxyprostaglandin Dehydrogenase in Osteoarthritis and Ankylosing Spondylitis: Associations With Clinical and Musculoskeletal Ultrasound Features.
Source: ClinicalTrials.gov · Last updated 7 Aug 2026
Brief summary (registry, in English)
To evaluate serum and synovial fluid 15-PGDH levels in patients with osteoarthritis and ankylosing spondylitis and determine their associations with clinical and musculoskeletal ultrasound features. To compare 15-PGDH concentrations among patients with knee osteoarthritis, and ankylosing spondylitis with knee effusion To evaluate whether serum 15-PGDH reflects intra-articular 15-PGDH concentrations. Analysis the level of 15-PGDH in relation to disease activity and severity of both diseases.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 51 (estimated)
- First submitted
- 3 Aug 2026
- Start date
- 2 Aug 2026
- Primary completion date
- 2 Aug 2027
- Lead sponsor
- Assiut University
- Diseases
- Ankylosing spondylitis
- NCT number
- NCT07751263
What you commit to
- Study type: Observational
- Planned participants: 51
- From 2 Aug 2026 to the primary completion date, 2 Aug 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- • Other inflammatory arthritides such as psoriatic arthritis, gout, or SLE-related arthritis.
- Septic arthritis or suspected joint infection.
- Recent intra-articular steroid injection if it may influence biomarker results.
- Any major systemic illness likely to affect biomarker measurement or ultrasound interpretation.
- Patients received certain drugs as non-steroidal anti-inflammatory drugs (NSAIDs)
Who the study is looking for
- Inclusion criteria
- Adults aged 18 years or older. AxSpA group Patients diagnosed as ankylosing spondylitis according to ASAS criteria . R OA group
- Adults with osteoarthritis Diagnosed according to the American College of Rheumatology classification criteria.\[8\]R ACR Clinical classification criteria for Osteoarthritis of the hip ACR Clinical classification criteria for Osteoarthritis of the knee ACR Clinical classification criteria for Osteoarthritis of the hand Control group Age- and sex-matched healthy controls.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.