NCT07752225Not yet recruiting
Long-term Effects of Avocado Consumption on Health in Pre-diabetic Individuals
Effects of Long-term Avocado Consumption on Brain and Peripheral Cardiovascular Health in Pre-diabetic Individuals
Source: ClinicalTrials.gov · Last updated 27 Aug 2026
Brief summary (registry, in English)
Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 34 (estimated)
- First submitted
- 3 Aug 2026
- Start date
- 1 Sept 2026
- Primary completion date
- 30 Jun 2028
- Lead sponsor
- Maastricht University Medical Center
- Diseases
- Obesity
- NCT number
- NCT07752225
What you commit to
- Study type: Interventional
- Planned participants: 34
- From 1 Sept 2026 to the primary completion date, 30 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Abuse of drugs
- Use of an investigational product within another biomedical intervention trial within the previous 1-month
- Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)
- Blood donation in the 8 weeks before the start of the study
Other illness
- Type 1 or type 2 diabetes
- Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis
- Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident
Lab values
- Fasting serum total cholesterol \> 8.0 mmol/L
- Use medication to treat blood pressure, lipid or glucose metabolism
Age
- Age less than 40 years old or older than 75 years
Other
- BMI \< 25 kg/m2
- habitual consumption of more than 1 avocado/ week
- Left-handedness
- Current smoker, or smoking cessation \< 12 months
- More than 3 alcoholic consumptions per day
- Difficulties to draw blood
Who the study is looking for
- Men and women, aged between 40-75 years
- Pre-diabetes: (A1C of 5.7%-6.4%, a fasting plasma glucose (FPG) of 100-125 mg/dL, or a 2-hour oral glucose tolerance test (OGTT) result of 140-199 mg/dL)
- BMI ³ 25 kg/m2
- Fasting serum total cholesterol \< 8.0 mmol/L
- Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 100 mmHg
- Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study
Age in the registry: 40 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Nutrition and Movement Sciences Coordinator of this site? Confirm its status | Maastricht | Netherlands | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.