NCT07752355Recruiting
Young Onset Parkinson's Disease Subtypes and Pathogenic Mechanisms
Source: ClinicalTrials.gov · Last updated 12 Aug 2026
Brief summary (registry, in English)
Young Onset Parkinson's disease (YOPD) refers to a group of patients in which the disease starts earlier in life (before the age of 50 years) and has a profound impact on most of patient's life. Current knowledge regarding the mechanisms leading to development of Parkinson's disease in younger individuals is lacking, but their understanding is crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. With this research the investigators aim to clarify the contribution of relevant biological processes in patients with Young onset Parkinson's disease to help understanding disease mechanisms and biomarkers.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 250 (estimated)
- First submitted
- 3 Aug 2026
- Start date
- 28 Feb 2024
- Primary completion date
- 31 Oct 2028
- Lead sponsor
- NYU Langone Health
- Diseases
- Parkinson disease
- NCT number
- NCT07752355
What you commit to
- Study type: Observational
- Planned participants: 250
- From 28 Feb 2024 to the primary completion date, 31 Oct 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Diagnosis of atypical parkinsonism (i.e. progressive supranuclear palsy, corticobasal degeneration, multiple system atrophy) or secondary parkinsonism (i.e. normal pressure hydrocephalus, drug-induced parkinsonism).
Other illness
- Clinical history of autoimmune or chronic inflammatory disorder or exposure to chronic immunosuppressant or immunomodulatory medications.
- Dermatological conditions that would prevent performing skin punch biopsies
Other
- Pregnancy
Who the study is looking for
- YOPD cohort:
- Male or female 18 years or older (inclusive) of any race and ethnicity
- Diagnosis of Parkinson's disease (PD) confirmed by a movement disorder specialist and with an age of onset of less than or equal to the age of 50 years old
- Willingness to undergo a skin punch biopsy
- LOPD cohort:
- Male or female 18 years or older (inclusive) of any race and ethnicity
- Diagnosis of PD confirmed by a movement disorder specialist and with an age of onset after the age of 50 years
- Healthy Control cohort:
- Male or female 18 years or older (inclusive) of any race and ethnicity
- Never been diagnosed with PD as reported by medical history and as assessed by study PI
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| NYU Langone Health Coordinator of this site? Confirm its status | New York | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.