NCT07754942Not yet recruiting
Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel Occlusion
Local-to-Systemic Inflammatory Biomarker Gradients and 90-Day Functional Outcomes in Patients With Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion Undergoing Mechanical Thrombectomy: A Prospective Observational Cohort Study
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
The goal of this observational study is to describe the local change in interleukin-6 (IL-6) across a blood clot in adults with acute ischemic stroke caused by anterior circulation large vessel occlusion who are undergoing mechanical thrombectomy. The main questions it aims to answer are: * Is the level of IL-6 different in arterial blood collected beyond the clot compared with arterial blood collected before the clot during mechanical thrombectomy? * Is the trans-thrombus IL-6 difference associated with functional independence 90 days after stroke and with complications related to reperfusion injury? There is no comparison group and no experimental treatment. Researchers will compare paired blood samples collected from opposite sides of the clot in the same participant. Blood collected from a peripheral vein at hospital admission will be used only as a supportive reference for systemic inflammation. Participants will: * Receive standard mechanical thrombectomy and stroke care determined by their treating clinical team. * Have small blood samples collected at planned time points, including paired arterial blood samples collected during the thrombectomy procedure. * Have clinical and imaging information collected from their medical records and have functional status assessed 90 days after stroke. The study will not delay or change standard stroke treatment.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 4 Aug 2026
- Start date
- 1 Aug 2026
- Primary completion date
- 1 Aug 2028
- Lead sponsor
- Zhongshan Hospital Xiamen University
- Diseases
- Stroke
- NCT number
- NCT07754942
What you commit to
- Study type: Observational
- Planned participants: 50
- From 1 Aug 2026 to the primary completion date, 1 Aug 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known active systemic infection, active malignancy, or chronic inflammatory/autoimmune disease requiring systemic immunosuppressive treatment, when these conditions are expected to substantially affect inflammatory biomarker measurements.
Other
- Posterior circulation large vessel occlusion.
- Mechanical thrombectomy not performed.
- Pregnancy or breastfeeding, if required by the local ethics committee.
- Enrollment in another interventional study that could affect inflammatory biomarker measurements or clinical outcome assessment.
- Inability to obtain informed consent, where consent from a legally authorized representative is not permitted or cannot be obtained.
Who the study is looking for
- Age 18 years or older.
- Acute ischemic stroke caused by anterior circulation large vessel occlusion, confirmed by routine vascular imaging or digital subtraction angiography.
- Undergoing clinically indicated mechanical thrombectomy according to routine clinical practice.
- Provision of written informed consent by the participant or legally authorized representative, in accordance with local ethics requirements.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongshan Hospital Xiamen University Coordinator of this site? Confirm its status | Xiamen | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.