NCT07756112Recruiting
Dynamics of Wound Healing in Patients With Obesity
Temporal Dynamics of Palatal Wound Healing With and Without Adjunctive Biologics in Patients With Obesity
Source: ClinicalTrials.gov · Last updated 22 Oct 2026
Brief summary (registry, in English)
Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug. First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 104 (estimated)
- First submitted
- 4 Aug 2026
- Start date
- 13 Oct 2026
- Primary completion date
- Oct 2029
- Lead sponsor
- University of Iowa
- Diseases
- Obesity
- NCT number
- NCT07756112
What you commit to
- Study type: Interventional
- Planned participants: 104
- From 13 Oct 2026 to the primary completion date, Oct 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Take medications that may affect healing or require changes to the planned surgery.
- Have had surgery before in the area where the current procedure will be performed.
Other illness
- Have a history of alcohol or drug abuse.
- Have a history of an autoimmune disease or condition.
Other
- Are unable or unwilling to provide your own informed consent.
- Currently smoke or have smoked in the past.
Who the study is looking for
- Be an adult who is undergoing any surgical procedure or volunteering to be part of the study
- Be able and willing to give informed consent on their own.
- Have good oral hygiene (keep their teeth and gums clean).
- Have a healthy roof of the mouth with no unusual shape, disease, or injury.
- Not have any active illness affecting their overall health.
- Not have a medical condition that can slow wound healing, such as uncontrolled type 2 diabetes.
- Not currently pregnant.
- Not have received a blood transfusion in the last 3 months.
- For normal-weight group (BMI less than than 30 kg/m2, waist circumference less than 35 inches for women or greater than 40 inches for men) or for obesity group (BMI greater than 30 kg/m2, waist circumference greater than 35 inches for women and greater than 40 inches for men).
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Iowa College of Dentistry and Dental Clinics Coordinator of this site? Confirm its status | Iowa City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.