NCT07756411Completed
Selective, Micropulse and Pattern Laser Trabeculoplasty in Medically Treated Open-angle Glaucoma.
Subvisible Laser Trabeculoplasty in Medically Treated Open-angle Glaucoma: a Randomized Three-arm Comparison of Selective, Micropulse and Pattern Delivery Protocols.
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
This randomized, single-centre, three-arm trial compared three subvisible laser trabeculoplasty delivery protocols in eyes with open-angle glaucoma already receiving intraocular pressure (IOP)-lowering medication: selective laser trabeculoplasty (SLT, 3-nanosecond pulses), micropulse laser trabeculoplasty (MLT, 577 nm with 15% duty cycle), and pattern laser trabeculoplasty (PLT, 5-ms pattern delivery). Ninety eyes of 90 patients were allocated 1:1:1 to a single 360-degree session and followed for 6 months. The primary outcome was IOP at 6 months, with an equivalence margin of +/-2.0 mmHg prespecified for pairwise comparisons. Secondary outcomes were percentage IOP change, number of IOP-lowering medications, cumulative treatment success (IOP reduction of at least 20% from baseline without an increase in medications), and adverse events. Outcome assessment was performed by a second ophthalmologist masked to allocation and to clinical history.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 90 (actual)
- First submitted
- 4 Aug 2026
- Start date
- 1 Feb 2025
- Primary completion date
- 1 Apr 2026
- Lead sponsor
- University of Udine
- Diseases
- Glaucoma, High blood pressure
- NCT number
- NCT07756411
What you commit to
- Study type: Interventional
- Participants enrolled: 90
- From 1 Feb 2025 to the primary completion date, 1 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- previous laser trabeculoplasty, iridotomy or iridoplasty.
- previous intraocular surgery other than uncomplicated cataract extraction.
- systemic medication known to affect intraocular pressure.
Other illness
- corneal disease precluding visualization of the trabecular meshwork or reliable applanation tonometry.
Other
- pregnancy.
Who the study is looking for
- adults with primary or secondary open-angle glaucoma.
- gonioscopically open angle confirmed by gonioscopy in the study eye.
- receiving intraocular pressure-lowering medication at entry, with an indication for subvisible laser trabeculoplasty according to standard practice at the unit (IOP inadequately controlled on medical therapy, intolerance of medical therapy, or both).
- written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Glaucoma Unit, Department of Medicine - Ophthalmology, University of Udine Coordinator of this site? Confirm its status | Udine | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.