NCT07756476Recruiting
Stroke Volume-based Fluid Resuscitation in AP
Stroke volUme-baSed Fluid resusciTAtIoN in AP (SUSTAIN)
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
The SUSTAIN Trial is a randomized control trial that allows for the control of aggressive hydration that is currently used in an inpatient setting, which can result is fluid overload in certain patients. With the impression that changes in stroke volume in individual patient will further improve the outcome.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 19 Mar 2026
- Start date
- 19 Mar 2026
- Primary completion date
- 19 Mar 2028
- Lead sponsor
- University of Southern California
- Diseases
- Stroke
- NCT number
- NCT07756476
What you commit to
- Study type: Interventional
- Planned participants: 80
- From 19 Mar 2026 to the primary completion date, 19 Mar 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- NYHA Class \>= II Heart Failure
Age
- Ages \<18 years old
Other
- Patients with the inability to preform a straight leg raise (i.e amputation)
- Patients with high risk of adverse event related to fluid resuscitation
- Child's B and C Cirrhosis
- Dialysis Requirement
- Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites
- Pregnant
- Incarcerated
- Unable to provide informed consent
Who the study is looking for
- Patients between the age of 18-75
- Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ohio State University Coordinator of this site? Confirm its status | Columbus | United States | Active, not recruiting |
| University of Southern California Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.