NCT07756801Not yet recruitingPhase 4
Capital Offload-Shock
Optimal Timing of Renal Replacement Therapy in Hypervolemic Cardiogenic Shock
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital death when compared to the current standard of care. The current standard of care is to wait until renal replacement therapy is clinically necessary.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 456 (estimated)
- First submitted
- 17 Jul 2026
- Start date
- 1 Dec 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- Ottawa Heart Institute Research Corporation
- NCT number
- NCT07756801
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 456
- From 1 Dec 2026 to the primary completion date, Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients whose care plan, as determined by the treating clinical team, will not include renal replacement therapy
- Decision has already been made by the treating clinical team to initiate renal replacement therapy
- Acute intoxication necessitating use of renal replacement therapy
- Recent renal replacement therapy (within 30 days)
Other illness
- Known end-stage renal disease (defined as an estimated glomerular filtration rate \<15 ml/min/1.73m2
- presentation with out-of-hospital cardiac arrest
Lab values
- Hyperkalemia with serum potassium \>/= 6mmol/L at the time of screening
- Severe metabolic acidosis with serum bicarbonate \</= 12 mmol/L at the time of screening
- Severe azotemia with serum urea \>/= 40 mmol/L at the time of screening
Who the study is looking for
- adult patients \>/= 18 years of age admitted to an intensive care unit
- Diagnosed clinically with Society for Cardiovascular Angiography and Interventions (SCAI) Class C or D cardiogenic shock
- Clinical or hemodynamic evidence of volume overload
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Ottawa Heart Institute Coordinator of this site? Confirm its status | Ottawa | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.