NCT07759700Recruiting
Bundle Branch Pacing to Preserve Ejection Fraction in Atrial Fibrillation Trial
Left Bundle Branch Area Pacing Versus Conventional Right Ventricular Pacing as Initial Strategy for Patients With Permanent Atrial Fibrillation and Preserved Left Ventricular Ejection Fraction Requiring Cardiac Pacing: an Open-label, Multicenter, Randomized Clinical Trial. - the BEAT Study -
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn whether left bundle branch area pacing, a technique designed to activate the heart's natural electrical conduction system, is better than conventional right ventricular pacing in adults with permanent atrial fibrillation, preserved heart pumping function, and a need for a pacemaker. The main questions it aims to answer are: Does left bundle branch area pacing reduce the risk of death, unplanned hospitalization for heart failure, or the need to replace the initial pacing system with biventricular pacing over 2 years? Does it better preserve heart function and quality of life, without increasing pacemaker-related complications? Researchers will compare left bundle branch area pacing with conventional right ventricular pacing. A total of 642 participants will be randomly assigned to receive one of these two pacing strategies. Participants will: Have a single-chamber pacemaker implanted using either left bundle branch area pacing or conventional right ventricular pacing Undergo electrocardiograms, echocardiograms, and pacemaker checks during 2 years of follow-up Attend follow-up visits approximately 2, 12, and 24 months after implantation Be contacted by telephone approximately 6 and 18 months after implantation Complete questionnaires about their health and quality of life at the beginning and end of the study
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 642 (estimated)
- First submitted
- 2 Aug 2026
- Start date
- 15 Oct 2026
- Primary completion date
- 14 Oct 2028
- Lead sponsor
- Poitiers University Hospital
- Diseases
- Heart failure, Atrial fibrillation
- NCT number
- NCT07759700
What you commit to
- Study type: Interventional
- Planned participants: 642
- From 15 Oct 2026 to the primary completion date, 14 Oct 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Any prior attempt at implantation of an implantable cardioverter defibrillator, cardiac resynchronization therapy or LBBA pacing
Other illness
- Chronic respiratory failure
Age
- Serious medical condition with life expectancy of \<2 years
- Pregnant or breastfeeding women, women of childbearing age who do not have effective contraception (hormonal/mechanical: per os, injectable, transcutaneous, implantable, intrauterine device, or surgical: tubal ligation, hysterectomy, total oophorectomy)
Other
- Indication for an implantable cardioverter defibrillator.
- Presence of a mechanical tricuspid valve
- Glomerular filtration rate \<40 mL/min/1,73m2 with CKD-EPI formula
- Persons benefiting from enhanced protection, i.e. minors, persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection, and finally patients in emergency situations
Who the study is looking for
- Age ≥ 18 years and \<90 years
- Atrial fibrillation requiring ventricular pacing because of
- rapid atrial fibrillation requiring atrioventricular node ablation; or
- slow atrial fibrillation i.e. ≤ 50 bpm on admission ECG).
- Left ventricular ejection fraction ≥50%.
- Affiliated person or beneficiary of the French social security scheme
- Having given their informed consent.
Age in the registry: 18 years to 90 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU Poitiers Coordinator of this site? Confirm its status | Poitiers | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.