NCT07759960Recruiting
Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors
Underwater Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Small Rectal Neuroendocrine Tumors: A Prospective, Multicenter, Non-inferiority Trial
Source: ClinicalTrials.gov · Last updated 12 Aug 2026
Brief summary (registry, in English)
Underwater endoscopic mucosal resection (UEMR) and endoscopic submucosal dissection (ESD) have both been reported to be two effective treatment methods for small rectal neuroendocrine tumor (NET). However, there is no consensus on the best method for the endoscopic resection of rectal NET. Therefore, we aimed to compare the efficacy and safety of UEMR and ESD for the treatment of small rectal NET.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 174 (estimated)
- First submitted
- 30 Jul 2026
- Start date
- 14 Apr 2026
- Primary completion date
- Oct 2029
- Lead sponsor
- Nanfang Hospital, Southern Medical University
- Diseases
- Neuroendocrine tumours
- NCT number
- NCT07759960
What you commit to
- Study type: Interventional
- Planned participants: 174
- From 14 Apr 2026 to the primary completion date, Oct 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Received resection of rectal neuroendocrine tumor by other surgical procedures;
Other illness
- Complicated with serious diseases such as malignant tumor, which may lead to shorter life expectancy, the research team considers that it is not suitable for inclusion in the study after comprehensive evaluation;
- Vulnerable groups such as pregnant women or patients with mental disorders;
Other
- Unable to tolerate ESD or UEMR as assessed by the research team;
- Rectal NET with lymph node metastasis or distant metastasis;
- Multiple rectal neuroendocrine tumors;
- Poor compliance, unable to cooperate with treatment.
Who the study is looking for
- Age from 18 to 75 years;
- With a high suspicion or evidence of rectal NET assessed using EUS, CT scan or colonoscopy;
- With tumor size ≤10 mm assessed by colonoscopy or EUS;
- Plan to receive UEMR or ESD treatment and provide written informed consent.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Nanfang Hospital, Southern Medical University Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.