NCT07762742Not yet recruiting
A Comparative Study of Percutaneous Pulsed Field Ablation Guided by Ultrasound Alone Versus Fluoroscopy in Patients With Atrial Fibrillation
Source: ClinicalTrials.gov · Last updated 13 Aug 2026
Brief summary (registry, in English)
This prospective, randomized, multicenter, open-label, non-inferiority interventional study aims to compare the therapeutic efficacy of percutaneous pulsed field ablation (PFA) guided by ultrasound alone versus fluoroscopy in patients with paroxysmal atrial fibrillation (AF). The success rate of complete electrical isolation of pulmonary veins during the procedure was compared to verify that ultrasound-only guidance is non-inferior to fluoroscopic guidance.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 276 (estimated)
- First submitted
- 29 Jul 2026
- Start date
- 15 Aug 2026
- Primary completion date
- 28 Feb 2029
- Lead sponsor
- China National Center for Cardiovascular Diseases
- Diseases
- Atrial fibrillation
- NCT number
- NCT07762742
What you commit to
- Study type: Interventional
- Planned participants: 276
- From 15 Aug 2026 to the primary completion date, 28 Feb 2029
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous history of catheter ablation or cardiac surgery for atrial fibrillation;
- Prior surgical history including patent foramen ovale closure, atrial septal defect closure or repair;
- Concomitant other tachyarrhythmias requiring catheter ablation (e.g., atrioventricular reentrant tachycardia, atrioventricular nodal reentrant tachycardia, atrial tachycardia, atrial flutter, Wolff-Parkinson-White syndrome, etc.);
Other illness
- Atrial fibrillation secondary to electrolyte imbalance, thyroid disorders, or reversible non-cardiac causes;
Age
- Women who are pregnant, breastfeeding, or of childbearing age with plans to become pregnant during the clinical trial;
Other
- Implantation of left atrial appendage occluder, mechanical mitral valve prosthesis, or valvuloplasty ring containing metallic materials;
- Persistent atrial fibrillation;
- Left atrial anteroposterior diameter (LAD) \> 55 mm on transthoracic echocardiography;
- Current participation in another pharmaceutical or medical device clinical study.
Who the study is looking for
- Adult patients aged 18 to 75 years (including 18 years and 75 years of age).
- Patients diagnosed with paroxysmal atrial fibrillation via 12-lead electrocardiography or ambulatory electrocardiography and scheduled to undergo pulsed field ablation.
- Subjects are able to understand the purpose of the study, voluntarily participate in the study and sign the informed consent, and are willing to complete the follow-up according to the requirements of the program.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.