NCT07770230Not yet recruiting
RADIATE-HF - Efficacy and Safety of Cardiac Radiation in Advanced Heart Failure
RADIATE-HF - Efficacy and Safety of Cardiac Radiation in Advanced Heart Failure: an Exploratory Single-Arm Study
Source: ClinicalTrials.gov · Last updated 11 Sept 2026
Brief summary (registry, in English)
The RADIATE-HF study is a prospective, interventional, single-center, open-label, non-randomized study conducted at the Rennes University Hospital. The goal of this proof-of-concept trial is to demonstrate that low-dose cardiac radiation therapy (5 Gy) improves left ventricular function by more than 5% in the medium term in patients with advanced or end-stage heart failure. The primary endpoint is the difference between the baseline value and the 6-month value of the LVEF as assessed by cardiac MRI. The study includes a single group of 20 patients receiving the intervention (cardiac radiation). The study is being conducted at a single investigator site.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 12 Aug 2026
- Start date
- 15 Sept 2026
- Primary completion date
- 31 Mar 2029
- Lead sponsor
- Rennes University Hospital
- Diseases
- Heart failure
- NCT number
- NCT07770230
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 15 Sept 2026 to the primary completion date, 31 Mar 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of thoracic radiotherapy
- History of aortic and mitral valve surgery
Other
- Pregnancy or breastfeeding
- Contraindications to MRI (claustrophobia, presence of metallic foreign bodies)
- Participation in another ongoing interventional study
- Adults subject to legal protection measures (judicial protection, guardianship, curatorship), deprived of their liberty, or unable to give informed consent.
Who the study is looking for
- Minimum age: 18 years
- Ischaemic or non-ischaemic cardiomyopathies
- Optimal medical treatment
- LVEF ≤ 40%
- NYHA class II or III
- Life expectancy \> 6 months
- At least one hospital admission for heart failure within the 6 months prior to inclusion, or NT-pro BNP ≥ 1,000 pg/mL
- Contraindications to heart transplantation and left ventricular or biventricular assist devices
- Having given their free and informed written consent
- Covered by a health insurance scheme
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Rennes University Hospital Coordinator of this site? Confirm its status | Rennes | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.