NCT07771868Recruiting
High-Intensity Interval Training for Walking and Function Across Different Multiple Sclerosis Disability Levels
The Effect of High-Intensity Interval Training on Maximum Walking Distance and Functional Parameters in Patients With Multiple Sclerosis at Different Disability Levels
Source: ClinicalTrials.gov · Last updated 10 Sept 2026
Brief summary (registry, in English)
Multiple Sclerosis (MS) is a chronic neurological disease that can affect daily functioning, mobility, and overall quality of life. High-Intensity Interval Training (HIIT) is known to be a time-efficient exercise approach that improves exercise capacity and reduces fatigue in MS. However, current research lacks sufficient data on how HIIT affects individuals with different levels of disability. The main purpose of this study is to evaluate the effects of a stationary bicycle-based HIIT protocol on maximum walking distance, fatigue, balance, muscle strength, endurance, gait speed, and quality of life in MS patients across three different disability levels: mild, moderate, and severe (classified according to Expanded Disability Status Scale - EDSS scores). Participants will complete a cycle ergometer-based HIIT program. Assessments will be conducted at three time points: Before starting the exercise program (baseline) Immediately after completing the program (post-treatment) 4 weeks after the completion of the program (follow-up) To ensure unbiased results, a triple-blind design will be used, meaning the outcome assessor, the treating physiotherapist, and the data analyst will be blinded to group assignments. The findings aim to help clinicians tailor personalized, effective HIIT protocols based on a patient's specific disability level rather than using a standardized, one-size-fits-all approach in MS rehabilitation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- First submitted
- 4 Aug 2026
- Start date
- 1 Sept 2026
- Primary completion date
- 31 Dec 2027
- Lead sponsor
- Hacettepe University
- Diseases
- Multiple sclerosis
- NCT number
- NCT07771868
What you commit to
- Study type: Interventional
- Planned participants: 30
- From 1 Sept 2026 to the primary completion date, 31 Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Having received a botulinum toxin injection within the last 3 months,
Other illness
- Having a severe cardiovascular, orthopedic, respiratory, or metabolic disease,
- Having an additional neurological condition,
Other
- Being pregnant or suspecting pregnancy,
- Having a COMPASS-31 total score greater than 13.6
Who the study is looking for
- Be between the ages of 18 and 65,
- Have been diagnosed with MS by a treating physician,
- Have an EDSS score between 0 and 6.5,
- Not having experienced a relapse within the last 3 months,
- Not having severe lower extremity contractures, severe spasticity (≥3 on the Modified Ashworth Scale), or an acute orthopedic problem that would prevent the participant from pedaling on a bicycle ergometer,
- Having a Mini Mental State Examination score of ≥24.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hatay Mustafa Kemal Universty Coordinator of this site? Confirm its status | Hatay | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.