NCT07772869Recruiting
Uterine Lavage to Detect Ovarian Cancer Risk
Collection of Uterine Lavage in High-Risk Patients as a Potential Biomarker for Ovarian Cancer Risk
Source: ClinicalTrials.gov · Last updated 14 Sept 2026
Brief summary (registry, in English)
This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations. Women with inherited mutations in the BRCA1 and BRCA2 genes (BRCA carriers) have a much higher lifetime risk of developing ovarian cancer. Currently there are no effective ovarian cancer screening or early detection tests for BRCA carriers. Uterine lavage is a procedure that uses saline to rinse and collect cells from the fallopian tube. Molecular analysis of these samples may help proactively detect genetic alterations that are indicative of progression to ovarian cancer in women with BRCA mutations.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 10 Aug 2026
- Start date
- 3 Sept 2026
- Primary completion date
- 1 Jun 2028
- Lead sponsor
- University of Washington
- Diseases
- Ovarian cancer
- NCT number
- NCT07772869
What you commit to
- Study type: Interventional
- Planned participants: 75
- From 3 Sept 2026 to the primary completion date, 1 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior tubal ligation
- Prior history of known ovarian or endometrial cancer
Who the study is looking for
- \> 18 years of age
- Have a pathogenic BRCA1 or BRCA2 germline variant
- Planned risk-reduction surgery
- Presence of uterus and at least one fallopian tube
Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fred Hutch/University of Washington Cancer Consortium Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.