NCT07772947Completed
Effects of Hyperbaric Oxygen Combined With Aerobic Exercise on Working Memory Among Stroke Patients
Effects of Combined Hyperbaric Oxygen Therapy and Moderate-Intensity Aerobic Exercise on Working Memory in Stroke Patients: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
This single-center randomized controlled trial enrolled stroke patients with working memory impairment. Participants were randomly divided into the hyperbaric oxygen combined low-intensity focused ultrasound intervention group and the conventional rehabilitation control group. The intervention lasted for a fixed course, and indicators including working memory performance and prefrontal cortex activation detected by fNIRS were compared before and after treatment. The study aims to verify whether combined intervention can better improve cognitive function in stroke survivors. All subjects signed informed consent and obtained ethical approval before enrollment.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 50 (actual)
- First submitted
- 14 Aug 2026
- Start date
- 6 Dec 2024
- Primary completion date
- 1 May 2025
- Lead sponsor
- Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University
- Diseases
- Stroke
- NCT number
- NCT07772947
What you commit to
- Study type: Interventional
- Participants enrolled: 50
- From 6 Dec 2024 to the primary completion date, 1 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Contraindications for hyperbaric oxygen therapy (untreated pneumothorax, severe emphysema etc.);
- Taking cognitive improvement drugs within 1 month before enrollment;
Other illness
- History of dementia, traumatic brain injury or other central nervous system diseases;
- Severe visual/auditory impairment unable to finish cognitive assessment;
- Severe cardiac insufficiency or unstable vital signs;
Other
- Dropping out voluntarily during the 14-day intervention.
Who the study is looking for
- First-ever ischemic stroke confirmed by cranial MRI/CT;
- Age 65-85 years old;
- MoCA score 18-26 points (mild cognitive impairment after stroke);
- Right-handed, able to complete 2-back cognitive task and fNIRS detection;
- Signed written informed consent voluntarily.
Age in the registry: 65 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Wuhan Sixth Hospital Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.