NCT07773064Recruiting
Identification for High Risk of Coronary Heart Disease Based on Quantitative Analysis of Fundus Vessels and Metabolic Molecules
Source: ClinicalTrials.gov · Last updated 20 Aug 2026
Brief summary (registry, in English)
This ambidirectional observational cohort study builds upon and expands an existing coronary artery disease (CAD) cohort based on retinal fundus imaging (ChiCTR2200066429). A comprehensive baseline database will be established, including demographic characteristics, laboratory test results, coronary angiography findings, quantitative retinal vascular features, and multi-omics data.Artificial intelligence methods will be used to quantify retinal vascular characteristics and to develop and validate models for identifying and predicting CAD. In addition, targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays will be developed to measure previously identified CAD-related biomarkers, including metabolites and lipids, in baseline biological samples. Clinical, retinal imaging, and multi-omics data will subsequently be integrated to develop a risk stratification model for identifying individuals at high risk of CAD. Participants will be followed for cardiovascular events to evaluate the predictive performance of the model. The findings may support the development of improved strategies for CAD detection, risk assessment, and clinical management. No treatment or clinical intervention is assigned by the study protocol, and all medical decisions are made as part of routine clinical care.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 3000 (estimated)
- First submitted
- 12 Aug 2026
- Start date
- 14 May 2024
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- Beijing Hospital
- Diseases
- Coronary artery disease
- NCT number
- NCT07773064
What you commit to
- Study type: Observational
- Planned participants: 3000
- From 14 May 2024 to the primary completion date, 31 Dec 2026
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of heart transplantation or other solid-organ transplantation
- History of severe congenital heart disease, valvular heart disease, myocardial disease, pericardial disease, or aortic dissection
- Progressive life-threatening disease
- History of alcohol or drug abuse
- Current treatment for a psychiatric disorder
- Current receipt of radiotherapy or chemotherapy for a malignant tumor
- Acute or chronic infectious disease
- Severe hepatic insufficiency, renal insufficiency, thyroid disease and autoimmune disease
- Ophthalmic diseases affecting the retinal vasculature or optic disc structure, including retinal artery occlusion, retinal vein occlusion, glaucoma, or congenital optic disc abnormalities
Lab values
- Severe heart failure, defined as New York Heart Association (NYHA) functional class IV or left ventricular ejection fraction (LVEF) ≤20%
Other
- Pregnancy, breastfeeding, or plans to become pregnant during the study period
- Life expectancy of less than 5 years
- Color fundus photographs of insufficient quality because of severe ocular media opacity
Who the study is looking for
- Older than 18 years
- Symptoms suggestive of myocardial ischemia or the presence of multiple cardiovascular disease risk factors
- Underwent coronary angiography during hospitalization
- Underwent blood sample collection during hospitalization
- Underwent bilateral color fundus photography during hospitalization
- Availability of complete clinical data
Age in the registry: 18 years to 100 years · Sex: All
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Friendship Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Not yet recruiting |
| Beijing Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
| Beijing Haidian Hospital Coordinator of this site? Confirm its status | Beijing | China | Completed |
This page is information, not medical advice. Discuss any trial with your doctor.